Researcher · Chemistry · Waterloo

Research Work

研 究 工 作

Postdoctoral researcher building molecular tools at the intersection of aptamer chemistry and functional nanomaterials.

/ Trackers — daily feeds

What the work keeps watching.

01 Daily · Local Streamlit

Aptamer Tracker

A daily-scoring tracker for aptamer literature — PubMed, OpenAlex, bioRxiv. Composite score combining impact factor, citation velocity, social signal, and recency. Six subtopics.

Open → Cadence: daily · window 14 days
02 External · Host lab

Juewen Liu Lab

Functional nucleic acids, nanozymes, and aptamer-based biosensors at the University of Waterloo — the host lab for the postdoctoral work described here. Group page lists current projects, members, and publications.

Visit → sites.google.com / view / liujuewen
/ Tools — open utilities

What the work has built.

03 Desktop · Windows + macOS

Aptamer Analysis Tool

SELEX FASTQ trim, family clustering, and PDF / PNG / XLSX / Word reports. Tunable EPS, three-tier trim modes, batch-mode unattended runs.

View & download → v0.7.3 · 122 / 141 MB
04 Web · No installation

Kd Fitting Tool

Quadratic binding-model Kd fitting from concentration / signal data. Paste from Excel, fit, export curve and image. Runs entirely in your browser.

View & launch → v0.22 · Provided by Liu Lab
05 Desktop · Windows · Single-file

AptaFold

DNA aptamer secondary-structure prediction with Na⁺ / Mg²⁺ / K⁺ / Ca²⁺ / temperature inputs and G-quadruplex detection. Replaces m-fold / UNAFold for routine SELEX lab use.

View & download → v0.6.7 · ~114 MB single-file .exe
06 Desktop · Windows · Experimental

Structural Family Classification

Classify SELEX-derived DNA aptamers by their loop-region structure instead of full-length sequence. Multi-structure folding + weak-helix dissolution + k-mer DBSCAN. Built on AptaFold + Aptamer Analysis.

View & download → v0.9.4 · experimental preview
/ Focus

What the work is about.

Aptamer selection (SELEX)

Capture-SELEX and tissue-SELEX for discovering DNA aptamers against small molecules and tissue targets.

Biosensor development

Label-free fluorescent sensors — ThT-based and FRET — for therapeutic drug monitoring, food safety, and environmental analysis.

Functional nanomaterials

Gold and silver nanoparticles, plasmonic photocatalysts, and carrier-free drug-delivery platforms.

Spherical nucleic acids

Aptamer–AuNP conjugates for targeted cell recognition, tissue staining, and ocular drug delivery.

Molecular characterization

Binding affinity, structure, and kinetics via ITC, NMR, CD, and fluorescence spectroscopy.

/ Path

Where the work has been done.

Now · 2024 →
Waterloo Ontario
2020 — 2024
Jinan Shandong
2018 — 2019
Aberdeen Scotland
2014 — 2017
Waterloo Ontario
2012 — 2014
Jinan Shandong
/ Contact

Selected publications and full CV available upon request.

[email protected]