Top aptamer papers on neurodegeneration — updated daily

Highest-scoring papers · 高分论文

1. Online aptamer-based solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry for the determination of Alzheimer's disease biomarkers

   Analytica chimica acta · IF 5.4 · 2026-10-01 · 1 citation · score 13.6

   BACKGROUND: Reliable quantification of amyloid-β (Aβ) peptides in biological fluids is of major clinical and research interest in Alzheimer disease context. Conventional offline extraction approaches often involve labor-intensive manual steps and high solvent consumption, limiting throughput routine applications,…

2. Membrane-Coated DNA Nanoflowers Attenuate Cognitive Decline in Apolipoprotein E4 Mice

   ACS applied materials & interfaces · IF 9.5 · 2026-09-24 · 0 citations · score 12.3

   APOE4-driven mitochondrial dysfunction is one of the important primary drivers of cognitive decline in neurodegenerative diseases. However, achieving mitochondrial-targeted drug delivery in the nervous system requires overcoming multiple barriers, necessitating the development of a safer and more efficient…

3. Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosomal function via Sirt3 signaling to ameliorate neurodegenerative pathology

   Neural regeneration research · 2026-10-01 · 0 citations · score 10.0

   Neuroinflammation and lysosomal dysfunction in microglia are increasingly recognized as critical pathological drivers of Alzheimer’s disease, yet current anti-inflammatory or neuroprotective agents have limited brain delivery efficiency and cellular specificity. To address these challenges, this study proposes a novel…

4. Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus

   Intensive care medicine experimental · 2026-09-29 · 0 citations · score 9.3

   BACKGROUND: Mechanical ventilation is associated with acute and long-term cognitive dysfunction, yet the molecular pathways linking ventilator-induced lung injury (VILI) to brain injury remain poorly characterized. We previously demonstrated that peripheral IL-6 signaling mediates delirium-like phenotypes in a murine…

5. Highly sensitive and specific high-throughput detection of Aβ42 in clinical specimens using a G-quadruplex-structured fluorescent aptamer analysis platform

   Talanta · IF 6.1 · 2026-09-17 · 0 citations · score 9.2

   The early diagnosis of Alzheimer's disease (AD) relies on highly sensitive detection of the biomarker amyloid-β 42 (Aβ42). Currently used methods for detecting Aβ42, such as enzyme-linked immunosorbent assay (ELISA) and mass spectrometry, have limitations including insufficient sensitivity, high cost, and limited…

6. Aptamer-Based Heterobifunctional Targeted Degraders in Disease Treatment

   Molecules (Basel, Switzerland) · IF 4.2 · 2026-09-18 · 0 citations · score 8.9

   Aptamers are short nucleic acid molecules that bind to targets with high specificity. Recognized as "chemical antibodies", they offer distinct advantages including strong programmability and ease of synthesis and chemical modification. Heterobifunctional targeted degraders were developed to address the challenges…

7. Split malachite green aptamer transcription-based AND logic fluorescent platform: A novel approach for dual-miRNA detection in diabetes mellitus complicated with Alzheimer's disease

   Microchemical Journal · IF 4.9 · 2026-09-16 · 0 citations · score 8.5

8. Vibrational Spectroscopy in Alzheimer's Disease Research and Diagnostics: From Molecular Biomarkers to Spectral Fingerprints

   Critical reviews in analytical chemistry · 2026-09-25 · 0 citations · score 8.0

   Alzheimer's disease (AD) research is increasingly shaped by biologically anchored criteria and blood-based biomarker workflows, but the role of vibrational spectroscopy within this landscape remains difficult to define because infrared (IR), Raman, and surface-enhanced Raman scattering (SERS) methods measure different…

9. Proteomic signatures during pregnancy: an exploratory cohort study of long-term health indicators

   EBioMedicine · 2026-09-22 · 0 citations · score 7.0

   BACKGROUND: Pregnancies complicated by fetal growth restriction (FGR) and preeclampsia are associated with increased long-term chronic disease risk. A blood test could possibly identify those at risk, opening the door to early interventions soon after delivery. Prior work in non-pregnant people have identified protein…

10. Author Correction: Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models

    Nature biotechnology · IF 33.1 · 2026-08-12 · 0 citations · score 6.9

11. Small Nucleic Acid Therapeutics for Ocular Diseases: Progress, Challenges, and Future Perspectives

    Pharmaceutics · 2026-09-20 · 0 citations · score 6.3

    Ocular diseases remain a major global health challenge with substantial unmet therapeutic needs. Small nucleic acid therapeutics offer a precise strategy to regulate disease-related mRNAs or noncoding RNAs through base pairing, thereby modulating protein expression at the RNA level. Major modalities include antisense…

12. Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42

    Talanta · IF 6.1 · 2026-08-15 · 1 citation · score 5.7

    Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath…

13. High-Performance Screen-Printed OECT-Inspired with Encased Cassette Based on PEDOT:GO for Sensitive and Specific Electrochemical Aptasensing of Aβ-42 in Management of Alzheimer's Disease

    ACS applied bio materials · IF 4.7 · 2026-09-07 · 0 citations · score 5.4

    Recently, substantial interest has emerged in developing point-of-care diagnostic devices for Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by the accumulation of beta-amyloid (Aβ1-42) peptides that act as critical biomarkers for early detection. In response to the growing demand for…

14. Preliminary Development of a Hybrid Aptamer and Antibody Fluorescent Lateral Flow Assay for Ultrasensitive Detection of Tau441 Protein in Serum: Toward Point-of-Care Diagnostics for Alzheimer's Disease

    Journal of fluorescence · IF 3.0 · 2026-09-09 · 0 citations · score 5.4

    A hybrid DNA aptamer and antibody-Europium nanoparticle (Eu NP) fluorescent sandwich lateral flow (LF) assay for Tau441 is described which works well in human serum with an apparent visible detection limit for Tau 441 of ~ 10 pg/ml or 1 pg of Tau protein. The same LF assay appears to detect phosphorylated threonine…

15. Development of an RNA aptamer as a therapeutic agent for synucleinopathies

    Nature communications · IF 14.7 · 2026-07-15 · 0 citations · score 5.4

    The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodegeneration. Despite the…

16. Aptamer-Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN-STAT3 Complex and Enables Liquid Biopsy Detection

    Advanced science (Weinheim, Baden-Wurttemberg, Germany) · IF 14.3 · 2026-05-19 · 0 citations · score 5.3

    Colorectal cancer (CRC) poses a significant global health challenge, highlighting the need for better diagnostic tools and molecular targets. Compared to traditional antibodies, aptamers, which are single-stranded oligonucleotides with high affinity and low immunogenicity, offer an ideal platform for discovering novel…

17. Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

    Advanced Science · IF 14.3 · 2026-07-20 · 0 citations · score 5.3

    Ultrasensitive detection of low-abundance protein biomarkers is crucial for early disease diagnosis but remains challenging for the conventional barcode beads-based suspension chip platform due to the limited detection sensitivity. Here, we report a conceptually novel reaction termed "radical-mediated in situ…

18. A signal-locked clamped hybridization chain reaction nanoamplifier for rapid and highly sensitive analysis of Aβ42

    Talanta · IF 6.1 · 2026-09-04 · 0 citations · score 4.8

    Amyloid-beta 42 (Aβ42) is a core biomarker associated with Alzheimer's disease (AD), but accurate quantification of low-abundance plasma Aβ42 remains challenging because of matrix interference, limited assay sensitivity, and time-consuming procedures in conventional methods. Herein, we developed an enzyme-free…

19. Screening molecular recognition element-based SWCNT optical sensors for the inflammatory cytokine TNF-α

    Biosensors & bioelectronics · IF 10.7 · 2026-05-27 · 0 citations · score 4.8

    TNF-α (Tumor Necrosis Factor) is a proinflammatory cytokine that amplifies inflammatory response and promotes leukocyte recruitment. TNF-α is primarily produced by activated macrophages, among others, in response to infection, inflammation, or tissue damage. Given its central role in normal and abnormal immune…

20. A label-free electrochemical aptasensor enables ultrasensitive and specific detection of neurofilament light

    Biosensors & bioelectronics · IF 10.7 · 2026-06-03 · 0 citations · score 4.8

    Plasma neurofilament light chain (NfL) has been identified as a promising early-stage Alzheimer's disease (AD) biomarker, reflecting neuroaxonal degeneration at preclinical stages. However, its extremely low concentration in blood presents a major analytical challenge. Although single-molecule array (Simoa) assays…