Aptamer 学术简报 — neurodegeneration — 2026-11-06

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 2 篇命中（aptamer 池 209 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [10.7] Structure-Guided Design of an m1A Demethylation-Activated Aptamer for Live-Cell Monitoring of ALKBH3 Demethylase Activity

Abstract AlkB homolog 3 (ALKBH3) is a demethylase that regulates nucleic acid modification dynamics, and dysregulated ALKBH3 activity is associated with various diseases, including cancers and neurodegenerative disorders. However, accurate monitoring of ALKBH3 demethylase activity in living cells remains challenging. Here, we report a structure-...

#2 [9.7] CRISPR-Cas Assays for Protein Detection: Strategies and Clinical Applications.

Measurement of protein biomarkers with high accuracy is critical for disease diagnostics and prognostic monitoring. However, conventional analytical platforms for protein detection suffer from insufficient sensitivity for low-abundance targets and require time-consuming, multi-step workflows. The CRISPR-Cas system is emerging as a powerful tool ...

Methodology