Aptamer 学术简报 — neurodegeneration — 2026-10-24

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 4 篇命中（aptamer 池 181 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [10.3] Mn-doped dual-emission CdZnSe/Mn:ZnS quantum dots for self-calibrated ratiometric sensing of Alzheimer's disease biomarker

#2 [9.3] Effects of a DNA Aptamer on α-Synuclein PFF–Induced Morphological Deficits in an in-vitro Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by the accumulation and propagation of pathological α synuclein (αSyn) aggregates, which contribute to neuronal dysfunction and morphological alterations. Previous work by our group has shown that the α-Syn-1 DNA aptamer, when co administered with toxic αSyn Pre-Formed Fibrils (PFFs), can halt the propag...

#3 [6.0] Multiplexed impedimetric zinc oxide nanorods-modified aptasensor on carbon ink-inscribed paper electrodes for the specific and sensitive co-detection of Alzheimer's and Parkinson's disease.

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), represent a growing health burden, while early diagnosis remains challenging because established diagnostic approaches, including cerebrospinal fluid analysis and neuroimaging, are invasive, expensive, and unsuitable for decentralized point-of-care testi...

#4 [5.3] Computationally guided engineering of an aptamer–gold nanoparticle aptasensor for ultrasensitive detection of α-synuclein in biological matrices

Early, reliable detection of α-synuclein (αSN) is critical for Parkinson's disease diagnosis, yet antibody-based assays remain limited by sensitivity, matrix effects, and cost. We report a label-free aptamer–gold nanoparticle nanobiosensor (G 12 Apt@AuNP) for non-invasive αSN detection in saliva. Molecular docking identified F5R1 as the aptamer ...

Methodology