Top aptamer papers on cancer — updated daily
The 20 highest-scoring aptamer papers on cancer, ranked by the formula below and rebuilt every day. Drawn from 618 matching papers (out of 2396 in the aptamer corpus) published 2026-01-01 to 2026-10-01 across 277 journals.
按下方公式排序的 cancer 方向高分适配体论文，每日重建。取自语料中命中该主题的 618 篇（全库 2396 篇），发表于 2026-01-01 至 2026-10-01，涉及 277 个期刊。
Highest-scoring papers · 高分论文
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Bifunctional Nanozymes for Synergistic Treatment by Boosting Oxidative Stress and Regulating the Protein Kinase B Pathway
Chemoresistance and dose-limiting toxicity remain major challenges in cancer chemotherapy, largely driven by aberrant activation of the protein kinase B (AKT) survival pathway. Although small-molecule AKT inhibitors can enhance chemosensitivity, their systemic activity frequently disrupts normal metabolic processes…
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Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma
Therapeutic strategies for glioblastoma have progressed considerably over recent decades. Despite the development of new biomedical technologies and advances in our understanding of physiology and disease progression, effective drug delivery to brain cancer remains a significant challenge. The challenge is delivering…
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A Self-Propelled DNA-Based Nanorobot for Hypoxic Tumor Therapy
Solid tumors pose major therapeutic hurdles due to pathophysiological barriers such as hypoxia and dense stroma, which severely restrict drug penetration. Conventional nanomedicines lack the autonomous capability to navigate these evolving obstacles. Here, we engineer a DNA‑based nanorobot constructed on an optimized…
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Synergistic MIP-aptamer dual-recognition on silver-decorated sulfur-doped graphene quantum dots (S-GQDs@Ag) nanohybrids for ultra-sensitive impedimetric carcinoembryonic antigen detection
The clinical utility of Carcinoembryonic Antigen (CEA) as a cornerstone biomarker for oncological monitoring is frequently hindered by the limitations of traditional immunoassays, including high costs, specialized storage requirements, and complex procedural workflows. To address these challenges, we report the…
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Integrating aptamer-transduced signal amplification and superwettable droplet microarrays for single-cell detection of cell surface vimentin
Metastasis is a leading cause of cancer-related mortality, with epithelial-mesenchymal transition (EMT) playing a critical role in this process. Cell surface vimentin (CSV) has emerged as a promising biomarker for detecting aggressive and metastatic tumor cells, requiring optimized analytical methods for its…
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Membrane-anchored catalytic hairpin assembly on exosomes: A fluorescent aptasensor for highly sensitive cancer diagnosis
Tumor exosomes serve as ideal biomarkers for the early diagnosis of cancer. However, the existing methods are characterized by low sensitivity and are prone to interference from free proteins. In this study, a fluorescent strategy was developed, which combines the enrichment of aptamer-functionalized microspheres with…
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DNA Nanoassembly Modified Polydopamine@MnO(2) Nanoparticles: Enhancement of miRNA-21 Downregulation for Reversal of Breast Cancer Drug-Resistance
Downregulating oncogenic microRNAs (miRNAs) is an attractive strategy for reversing drug resistance in cancer therapy. Compared to antisense, DNAzyme (Dz) possesses advantages such as recyclability and stability. However, it still suffers from insufficient stability and inadequate endogenous cofactors. Herein, by…
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Inhalable mucus-penetrating and senescence-targeted nanoliposomes reverse senescence to overcome chemoresistance for enhanced lung cancer therapy
Lung cancer therapy is severely hindered by the pulmonary mucus barrier and chemotherapy resistance driven by therapy-induced senescence (TIS) following DNA-damaging agents. Herein, we report an inhalable, mucus-penetrating nanoliposomes (DR@DPPC-Apt) engineered by incorporating an L1 cell adhesion molecule…
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An Exosome-Based Affinity Screening Platform for Identifying Bioactive Compounds against Colon Cancer
Abstract Exosomes, nanoscale extracellular vesicles carrying native membrane proteins, play crucial roles in intercellular communication and are critically involved in colorectal cancer progression and drug resistance, thereby offering a biologically relevant platform for targeted drug discovery. In this study, we…
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Isolation and Purification-Free Digital Single-Small Extracellular Vesicle Biosensing with Scalable Plasmonic Arrays
Abstract Recent advances in plasmonic biosensing and imaging have enabled label-free analysis of single biological nanoparticles. We previously developed PlAsmonic NanOapeRture lAbel-free iMAging (PANORAMA) for isolation and purification-free, digital counting and precise localization of antibody captured,…
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Ni-C@MOF-Apt microspheres with enzyme activity and photodynamic properties for capture and clearance of MCF-7 cells
Circulating tumor cells (CTCs) carry a migration risk, prone to forming metastatic foci and exacerbating the disease. Therefore, it is of great importance to improve the capture efficiency and killing effect of CTCs. First, Ni-doped covalent organic framework (Ni-COF) is used as a precursor for calcination at 900 °C,…
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Cascade-Amplified Microfluidic Detection of Tumor Biomarkers via Metal-DNA Nanospheres Activating CRISPR-Cas12a Assay
Abstract The development of ultrasensitive protein detection platforms is pivotal for early cancer diagnosis, yet existing methods are often constrained by inefficient “protein-to-signal” conversion and complex instrumentation. While CRISPR-Cas-based biosensors offer higher sensitivity for nucleic acids, their…
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A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing
Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR…
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Leukemic Stem Cell-Targeted Liposomal Nanoimmunotherapy Reverses Immune Evasion and Inhibits Fusion Oncoprotein-Driven Acute Myeloid Leukemia by Silencing B-Cell Lymphoma 2
Acute Myeloid Leukemia (AML) is a prevalent and aggressive hematologic cancer driven by leukemic stem cells and immune evasion. Among its subtypes, Mixed Lineage Leukemia-AF9 (MLL-AF9)- rearranged AML is exceptionally lethal, with B-cell lymphoma 2 (Bcl2), a key anti-apoptotic protein, supporting leukemic survival and…
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A self-powered biosensing platform for U937 cell detection and the induction of mitochondrial aggregation
An EBFC platform was developed for U937 cell detection via aptamer-triggered glucose oxidation. The generated electrons reduced cathode Fe3+, disrupting an alginate hydrogel to release mitochondrial-targeting nanoparticles. Intracellularly, ATP-induced DNA hybridization caused mitochondrial aggregation and…
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A target-activated AS1411 aptamer probe for in vivo and ex vivo imaging of nucleolin-overexpressing triple-negative breast cancer
Background Fluorescence imaging of breast cancer is often limited by high background signals from conventional “always-on” probes. The nucleolin-targeting AS1411 aptamer provides a promising recognition element for tumors with elevated nucleolin expression, including triple-negative breast cancer (TNBC). This study…
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Thermosensitive NIR-II fluorescence nanotracer for targeted detection of sentinel lymph nodes
Current tracers for sentinel lymph node (SLN) biopsy in breast cancer suffer from limitations including poor accumulation, short retention times, and background staining interference at the surgical site. To address these shortcomings, we developed a dual-functional thermoresponsive nanotracer based on PbS quantum…
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CD-73 blocking black phosphorus nanosheets hitchhiked on erythrocytes via affinity difference of AS1411 aptamer for targeted photothermal-immunotherapy of lung cancer
Metabolic checkpoint inhibition targeting adenosine signaling combined with photothermal therapy (PTT) can remodel the immunosuppressive tumor microenvironment and enhance antitumor immunity in lung cancer, but its efficacy is limited by tumor-targeted accumulation. Leveraging the differential binding affinity of…
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Upconversion nanoplatform unlocks the theranostic potential of Lu-177 radiotherapy via c-MET axis targeting in head and neck squamous cell carcinoma
Upconversion nanoparticles (UCNPs) convert tissue-penetrating near-infrared photons into sharp visible emissions, offering background-free optical readouts for deep-tissue imaging. Here we report multilayer NaLuF4:Yb,Tm@NaLuF4 UCNPs that simultaneously act as fluorescent probes and radioisotope precursors. Under 980…
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Enhancing the Diagnostic Performance of Early Lung Cancer by Integrating Multiplex Nucleic Acid Aptamer Detection With Conventional Tumor Markers: A Prospective Observational Study
OBJECTIVES: To evaluate the value of incorporating multiplex nucleic acid aptamer detection into conventional serum tumor marker testing for improving the early diagnosis of lung cancer. METHODS: This prospective observational study enrolled 158 participants, including patients with pathologically confirmed lung…
How this list is built · 这份榜单怎么来的
Sources. PubMed, OpenAlex and bioRxiv are polled daily for aptamer-related publications; records are de-duplicated by DOI.
Topic filter. A paper enters this list when its title or abstract matches any of: cancer, tumor, tumour, tumours, oncolog*, carcinoma, leukemia, leukaemia, lymphoma, metastasis, metastatic, neoplasm, malignan*, HER2, EGFR, PD-L1, CTC, circulating tumor, glioma, melanoma (SQLite FTS5, case-insensitive, * is a prefix wildcard). A paper can belong to several topics.
Ranking. composite = 0.45×log(IF) + 0.35×log(citation velocity) + 0.10×social + 0.10×recency, scaled to 100. Citation velocity is citations per day since publication, so a recent paper accruing citations quickly can outrank an older one with a larger total. The recency term decays linearly to zero at 30 days, so anything older than a month is ranked on impact and citation velocity alone — this list therefore tilts towards recent work by design.
What this is not. The ranking is computed from metadata — journal impact factor, citation counts, recency — not from reading the papers. It is a triage aid for deciding what to read, not a quality judgement or a substitute for a systematic review. Impact factor is missing for some venues (preprints in particular) and those papers score lower than their content may deserve.
这份榜单由元数据算出——期刊影响因子、引用数、时效性——而不是通过阅读论文得到。它是决定「先读哪篇」的分诊工具，不是质量判断，也不能替代系统综述。部分来源（尤其预印本）没有影响因子，其得分会低于内容应得的水平。
Where these papers appear · 语料期刊分布
| Journal | Papers | IF |
|---|---|---|
| Analytical chemistry | 24 | 6.7 |
| Analytical Chemistry | 23 | 6.7 |
| Talanta | 23 | 6.1 |
| Biosensors & bioelectronics | 21 | 10.7 |
| Figshare | 14 | — |
| Zenodo (CERN European Organization for Nuclear Research) | 13 | — |
| Mikrochimica acta | 11 | 5.4 |
| ACS sensors | 9 | 8.2 |
Daily archive · 每日归档（30 期）
- 2026-10-01
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