Aptamer 学术简报 — cancer — 2026-11-07

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 53 篇命中（aptamer 池 205 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.3] Single-Step Electrochemical Aptasensor for Melatonin Detection in Unprocessed Plasma.

Melatonin is a clinically relevant biomarker for diagnosing circadian rhythm sleep disorders (CRSDs) and monitoring circadian disruption associated with cancer, metabolic and cardiovascular disease, and psychiatric disorders. This work reports the implementation of an electrochemical aptamer-based biosensor (E-aptasensor) for direct reagentless ...

#2 [14.2] Dual DNA Nanomaterial-Regulated Homogeneous Immunoreaction-Enabled One-Step Electrochemical Analysis of Multiple Biomarkers in Clinical Samples

Abstract Homogeneous immunoassays offer a streamlined alternative to traditional heterogeneous methods by eliminating separation and washing steps. However, they are often hampered by low sensitivity, matrix interference, and limited multiplexing capability. Herein, we reported a dual DNA nanomaterial-based homogeneous electrochemical immunoassa...

#3 [14.2] Visualizing Single-Cell Secretion with Electrochemiluminescence Imaging.

Secretory proteins encode cellular states not only through their abundance but also through their intracellular transport before being released. However, visualizing protein secretion behavior with molecular specificity and a low background remains challenging. Here, we report VEGF-responsive electrochemiluminescence (ECL) nanoemitters that enab...

#4 [12.7] From recognition to delivery: nucleic acid aptamers in miRNA-related diagnosis and therapy of hepatocellular carcinoma

Hepatocellular carcinoma (HCC), the most common primary malignant liver tumour, remains a major clinical challenge because of its low early diagnosis rate and high post-treatment recurrence. MicroRNAs (miRNAs) play key regulatory roles in HCC development and progression and are potential liquid biopsy biomarkers and therapeutic targets. However,...

#5 [12.1] Expanding synthetic lethality through computationally designed aptamers

Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightforward sequence optimization. They have been developed for tumor recognition, biomarker detection, targeted delivery of drugs and therapeutic RNAs, and direct modulation...

#6 [12.0] NIR-II-Accelerated 2D-on-2D Silicene/MOF Heterointerfaces Disrupt Tumor Redox Homeostasis for Targeted Ferroptosis.

Catalytic ferroptosis therapy provides an attractive approach for tumor treatment, but its practical efficacy is often limited by insufficient reaction kinetics and the strong redox buffering capacity of the tumor microenvironment. Herein, we report an interface-engineered 2D-on-2D catalytic nanoplatform, SNs/FTC@Apt-P (SFTCP), constructed by in...

#7 [11.8] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers.

Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells toward ca...

#8 [11.6] A photoregulated DNA nanoflower for spatiotemporally controlled monitoring of adenosine triphosphate in living cells.

Visualization of adenosine triphosphate (ATP) dynamics in living cells is crucial for revealing metabolic abnormalities in tumors. Although DNA-based fluorescent probes show promise for biomolecular detection, their application in intracellular imaging faces several challenges, including insufficient cellular uptake efficiency and nonspecific si...

#9 [11.2] A pH/miR-21 dual-responsive multifunctional DNA tetrahedron for targeted tumor imaging and synergistic chemo-gene therapy.

Small interfering RNA (siRNA) presents promising prospects as a therapeutic agent; its clinical application is constrained by challenges such as inefficient delivery and off-target effects. This study developed a multifunctional DNA Tetrahedron (MDT) platform for synergistic delivery of siRNA and the chemotherapeutic agent doxorubicin (DOX) to o...

#10 [11.0] Metal nanoparticle based biosensors for biomarker recognition: a review.

The determination of blood biomarkers in blood, tissues or other body fluids is crucial for many therapeutic and pathological interventions. Recently, metal nanoparticle-based biosensors have gained significant attention for the sensitive detection of such relevant biomarkers. This review summarizes recent advances in biosensors, based on copper...

Methodology