Aptamer 学术简报 — cancer — 2026-10-30

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 44 篇命中（aptamer 池 208 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.5] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers.

Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells toward ca...

#2 [13.3] Exosome‐Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi–Chemo Therapy Through Cholesterol‐Free, Tumor‐Preferential Delivery

Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are developed to embed three exosoma...

#3 [13.3] IMAN: An Integrated Colorimetric Sensor for Direct Detection of PD-L1 on Extracellular Vesicles in Lung Cancer Diagnosis.

Lung cancer is a leading cause of cancer mortality, yet early diagnosis remains difficult, highlighting the need for sensitive, noninvasive methods. Extracellular vesicles (EVs) and their surface proteins (e.g., PD-L1) are promising biomarkers; nevertheless, current EV detection requires time-consuming purification, sophisticated instrumentation...

#4 [13.0] CRISPR/Cas13a-Regulated SERS Biosensor Based on Plasmonic-Enhanced Magnetic Rods with Intensified Electromagnetic Field Generation for Breast Cancer Associated miRNA Detection

Abstract Early and sensitive detection of breast cancer biomarkers is essential for improving patient prognosis, yet rapid and amplification-free analysis of low-abundance circulating miRNAs remains challenging. Herein, we report a CRISPR/Cas13a-regulated surface-enhanced Raman scattering (SERS) biosensor, termed the CaRER sensor, for on-site de...

#5 [12.8] An Integrated Cascade-Amplified Microfluidic Biosensor for Reconfigurable Profiling of CRC-Associated Faecal Extracellular Vesicle Surface Proteins.

Faecal extracellular vesicles (EVs) provide disease-relevant molecular information for non-invasive colorectal cancer (CRC) analysis. However, sensitive EV surface protein profiling remains challenging because low-abundance targets are obscured by heterogeneous vesicles and complex matrices. Here, an integrated cascade-amplified microfluidic bio...

#6 [12.3] Engineering aptamer-based therapeutics for precision cancer immunotherapy: from molecular targeting to clinical applications

Although cancer immunotherapy has revolutionized cancer therapy, the clinical efficacy of this approach is restricted due to tumor heterogeneity, immune escape, therapeutic resistance, poor tumor penetration, and toxic side effects. Short single-stranded DNA or RNA oligonucleotides, termed aptamers, have high affinity for a given target, low imm...

#7 [12.3] A DNA Logic-Gated Cascade Amplification Biosensor for Highly Specific Electrochemical Detection of Circulating Tumor Cells.

Circulating tumor cells (CTCs) are rare cancer-derived cells in peripheral blood, carrying vital information about tumor heterogeneity and progression. Their reliable detection remains challenging due to extreme rarity and high background interference. Herein, we report an electrochemical biosensor that integrates a DNA-based AND logic gate with...

#8 [12.3] Engineering a Reconfigurable Transmembrane Receptor Enables Logic-Controlled Signal Translocation.

Transmembrane receptors relay extracellular cues into intracellular responses through reconfigurable conformational changes, yet engineering synthetic systems that emulate receptor-like signal translocation with programmable control remains challenging. Here, we engineer a reconfigurable transmembrane receptor that enables logic-controlled signa...

#9 [12.2] A Bispecific Nanobridge Derived from Immunogenic Tumor Membranes Restores Dendritic Cell-T Cell Crosstalk for Enhanced Solid Tumor Immunotherapy.

In solid tumors, communication between dendritic cells (DCs) and T cells is impaired by poor immune infiltration and lack of physical contact, limiting current immunotherapies. Here, we develop a bispecific immune-bridging platform (NVMB) to address these limitations. NVMB consists of tumor cell membrane-derived nanovesicles enriched with damage...

#10 [12.2] Cascade DNA walker-driven photo-controlled CRISPR/Cas12a nanorobot enabling ultrasensitive one-pot detection of dual miRNAs in triple-negative breast cancer

Methodology