Top aptamer papers on biosensors — updated daily
The 20 highest-scoring aptamer papers on biosensors, ranked by the formula below and rebuilt every day. Drawn from 1450 matching papers (out of 2396 in the aptamer corpus) published 2026-01-01 to 2026-10-01 across 334 journals.
按下方公式排序的 biosensors 方向高分适配体论文，每日重建。取自语料中命中该主题的 1450 篇（全库 2396 篇），发表于 2026-01-01 至 2026-10-01，涉及 334 个期刊。
Highest-scoring papers · 高分论文
-
Recognition Mechanism of Serotonin by a G‐Quadruplex–Duplex Hybrid Aptamer
ABSTRACT Serotonin is a key neurotransmitter, and aptamer‐based tools using the 44‐nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high‐resolution NMR structures of Apt38, a 6‐nt…
-
Recognition Mechanism of Serotonin by a G-Quadruplex-Duplex Hybrid Aptamer
Serotonin is a key neurotransmitter, and aptamer-based tools using the 44-nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high-resolution NMR structures of Apt38, a 6-nt truncated…
-
Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment
In vivo continuous molecular monitoring represents a long-standing, transformative objective in medicine, with the potential to fundamentally reshape disease diagnostics, therapeutic decision-making, and long-term patient management by providing dynamic biochemical information that is currently inaccessible.…
-
Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring
ABSTRACT Accurate and in situ detection of uracil‐DNA glycosylase (UDG) is crucial for clinical diagnosis and prognosis assessment. However, conventional methods show low accuracy, limited sensitivity, and off‐target signal leakage due to flawed signal input/output and amplification mechanisms. Therefore, an…
-
Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities
ABSTRACT Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real‐time collection of photoelectrochemical signals in…
-
Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities
Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real-time collection of photoelectrochemical signals in brain…
-
An ultrasensitive colorimetric platform for tetracycline based on the aptamer tailoring strategy and synergistic signal amplification of Au@Ce MOF
In this study, a rapid Au@Ce MOF-Apt functionalized three-dimensional (3D) paper platform was constructed for the detection of TC in milk. To obtain a high-affinity aptamer (Apt), based on truncation and base mutation, resulting in high-affinity G-rich sequence aptamer (Apt-M24) (27 nt, -10.4 kcal/mol). Subsequently,…
-
Group detection of phthalates from mulches: Two competitive aptamer-based electrochemical approaches
Phthalates, known as endocrine disruptors, are often contained in plastic-based materials and may enter food webs, threatening human health. In this study, an oligonucleotide-based competitive assay for phthalates detection was built on an electrochemical platform, based on poly(l-glutamic acid) and gold…
-
High-sensitivity simultaneous discrimination and detection of structurally similar adenosine phosphates via DNA aptamer conformational changes in α-hemolysin nanopore
Adenosine phosphates (ATP, ADP, and AMP) play critical roles in cellular processes, yet their simultaneous detection remains challenging due to high structural similarity. To overcome this limitation, we developed a nanopore-aptamer sensing platform capable of tracking single-molecule binding dynamics in real time.…
-
Synergistic MIP-aptamer dual-recognition on silver-decorated sulfur-doped graphene quantum dots (S-GQDs@Ag) nanohybrids for ultra-sensitive impedimetric carcinoembryonic antigen detection
The clinical utility of Carcinoembryonic Antigen (CEA) as a cornerstone biomarker for oncological monitoring is frequently hindered by the limitations of traditional immunoassays, including high costs, specialized storage requirements, and complex procedural workflows. To address these challenges, we report the…
-
A bioelectrochemical aptamer sensor using vanadium-porphyrinic metal-organic framework for noninvasive hydrocortisone monitoring in sweat
Hydrocortisone (HC) is a vital steroid hormone secreted by the adrenal cortex that regulates how the body responds to stress, the immune system and metabolism. The primary objective of this study is the fabrication of an electrochemical aptamer sensor founded on a vanadium-porphyrin metal-organic framework (V-PMOF) to…
-
Integrating aptamer-transduced signal amplification and superwettable droplet microarrays for single-cell detection of cell surface vimentin
Metastasis is a leading cause of cancer-related mortality, with epithelial-mesenchymal transition (EMT) playing a critical role in this process. Cell surface vimentin (CSV) has emerged as a promising biomarker for detecting aggressive and metastatic tumor cells, requiring optimized analytical methods for its…
-
Multiplexed electrochemical aptasensor on a nanoporous electrode: towards sensitive and anti-fouling detection of procaine, ATP and adenosine in biofluids
This study presents a green and simple one-step electrochemical strategy for preparing nanoporous gold electrodes. The method involves anodizing the gold electrode by linear sweep voltammetry (LSV) in an aqueous solution of l-ascorbic acid (AA) and hydrochloric acid (HCl). The gold electrodes were etched in solution…
-
An electrochemical aptasensor based on PtPd NPs/g-C(3)N(4) and a locked DNAzyme amplification strategy for ultrasensitive ATP detection
Adenosine triphosphate (ATP) is a widely recognized indicator of microbial contamination, and its rapid and accurate detection is essential for assessing microbial pollution in food safety. Herein, an electrochemical aptasensor integrating a dual-signal amplification strategy was developed for ultrasensitive detection…
-
Membrane-anchored catalytic hairpin assembly on exosomes: A fluorescent aptasensor for highly sensitive cancer diagnosis
Tumor exosomes serve as ideal biomarkers for the early diagnosis of cancer. However, the existing methods are characterized by low sensitivity and are prone to interference from free proteins. In this study, a fluorescent strategy was developed, which combines the enrichment of aptamer-functionalized microspheres with…
-
A dual-mode electrochemical-colorimetric aptasensor based on HCR-CRISPR/Cas12a cascade amplification for MTGase detection
Microbial transglutaminase (MTGase) is widely used in food processing, but its potential food safety risks cannot be neglected. MTGase-treated wheat products show immunoreactivity, which may induce celiac disease and damage intestinal barrier function. Therefore, trace detection of MTGase is of great significance. In…
-
Aptamer-Functionalized Copolymer Films for Label-Free Capacitive Detection of Dopamine
Dopamine (DA) plays a central role in regulating neural function, and its reliable detection is essential for both fundamental neuroscience research and bioanalytical applications. Capacitive biosensors combined with aptamer recognition offer a label-free sensing strategy; however, constructing reproducible and…
-
An anti-fouling photoelectrochemical-electrochemical sensing platform with a zwitterionic interface and a photocurrent-polarity-switching strategy
In this work, we have developed a photoelectrochemical-electrochemical (PEC-EC) dual-mode sensing platform consisting of a polydopamine (PDA)-poly(sulfobetaine methacrylate) (PSBMA) anti-fouling zwitterionic interface equipped with a photocurrent-polarity-switching strategy. The PSBMA-PDA copolymer anti-fouling layer…
-
Matrix conditioning and magnetic bead target transfer for fluorescence aptamer-CRISPR/Cas12a detection of kanamycin in river water
Fluorescence aptamer-CRISPR/Cas12a assays provide efficient signal conversion and amplification for the detection of small molecules. However, their practical application in complex environmental water remains limited. Matrix components can cause signal loss before CRISPR amplification. In this study, a fluorescence…
-
Target-sensitive aptasensor FRET readout using a fluorescent nucleobase surrogate for detection of ochratoxin A
A target-sensitive FRET aptasensor platform is reported for ochratoxin A (OTA) detection. The intrinsic emission of OTA serves as the FRET donor to an internal fluorescent merocyanine nucleobase FRET acceptor. The platform achieves low nanomolar sensitivity and high selectivity over the nonchlorinated ochratoxin B…
How this list is built · 这份榜单怎么来的
Sources. PubMed, OpenAlex and bioRxiv are polled daily for aptamer-related publications; records are de-duplicated by DOI.
Topic filter. A paper enters this list when its title or abstract matches any of: biosensor*, aptasensor*, electrochemical sens*, fluorescen* sens*, colorimetric, detection, lateral flow, point-of-care, LOD, limit of detection, SPR, surface plasmon (SQLite FTS5, case-insensitive, * is a prefix wildcard). A paper can belong to several topics.
Ranking. composite = 0.45×log(IF) + 0.35×log(citation velocity) + 0.10×social + 0.10×recency, scaled to 100. Citation velocity is citations per day since publication, so a recent paper accruing citations quickly can outrank an older one with a larger total. The recency term decays linearly to zero at 30 days, so anything older than a month is ranked on impact and citation velocity alone — this list therefore tilts towards recent work by design.
What this is not. The ranking is computed from metadata — journal impact factor, citation counts, recency — not from reading the papers. It is a triage aid for deciding what to read, not a quality judgement or a substitute for a systematic review. Impact factor is missing for some venues (preprints in particular) and those papers score lower than their content may deserve.
这份榜单由元数据算出——期刊影响因子、引用数、时效性——而不是通过阅读论文得到。它是决定「先读哪篇」的分诊工具，不是质量判断，也不能替代系统综述。部分来源（尤其预印本）没有影响因子，其得分会低于内容应得的水平。
Where these papers appear · 语料期刊分布
| Journal | Papers | IF |
|---|---|---|
| Talanta | 143 | 6.1 |
| Biosensors & bioelectronics | 80 | 10.7 |
| Analytical Chemistry | 70 | 6.7 |
| Analytical chemistry | 69 | 6.7 |
| Microchemical Journal | 39 | 4.9 |
| ACS sensors | 35 | 8.2 |
| Food chemistry | 31 | 8.8 |
| Sensors and Actuators B Chemical | 31 | 8.0 |
Daily archive · 每日归档（30 期）
- 2026-10-01
- 2026-09-30
- 2026-09-29
- 2026-09-28
- 2026-09-27
- 2026-09-26
- 2026-09-25
- 2026-09-24
- 2026-09-23
- 2026-09-22
- 2026-09-21
- 2026-09-20
- 2026-09-19
- 2026-09-18
- 2026-09-17
- 2026-09-16
- 2026-09-15
- 2026-09-14
- 2026-09-13
- 2026-09-12
- 2026-09-11
- 2026-09-10
- 2026-09-09
- 2026-09-08
- 2026-09-07
- 2026-09-06
- 2026-09-05
- 2026-09-04
- 2026-09-03
- 2026-09-02