Aptamer 学术简报 — biosensor — 2026-10-30

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 105 篇命中（aptamer 池 208 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.9] A bifunctional triblock zwitterionic copolymer combined with gold nanostars for antifouling electrochemical aptasensor to detect chloramphenicol in food samples.

To address the issue of electrochemical sensors being susceptible to fouling interference in complex food matrices, this work proposed a high-performance antifouling aptasensor based on a triblock zwitterionic copolymer and a gold nanostars (Au NSs) conductive substrate. Through precise control over the composition of two zwitterionic monomers [...

#2 [14.6] Amplifying the invisible: Liquid crystal-hydrogel microcavities decode trace Hg ions and aflatoxin B1.

Chinese herbal medicines (CHMs) have been applied to the prevention and treatment of numerous diseases. Ensuring the safety and pharmacological efficacy of CHMs demands precise detection of trace heavy metal ions and toxins, especially Hg and aflatoxin B1 (AFB1). However, due to subtle chemical signals, current technologies still make it challen...

#3 [13.7] Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans ‐Cleavage for Rapid and Sensitive Nucleic Acid Detection

ABSTRACT CRISPR–Cas12a molecular diagnostics rely on target‐activated collateral cleavage of single‐stranded DNA (ssDNA) reporters to generate fluorescence signals, yet the mechanisms governing reporter substrate processing remain poorly understood. Here we show that Cas12a trans ‐cleavage involves both endonucleolytic cleavage and exonucleolyti...

#4 [13.4] Unconventional DNA architecture in a dopamine–bound aptamer complex

Abstract Aptamers are oligonucleotides that have been selected to bind a particular target. Despite the growing popularity of functional DNA aptamers, there remains limited knowledge of their binding mechanisms, as few have been characterized at the atomic level. Here, we use NMR spectroscopy to obtain structural details of RKEC1, a shortened ve...

#5 [13.3] IMAN: An Integrated Colorimetric Sensor for Direct Detection of PD-L1 on Extracellular Vesicles in Lung Cancer Diagnosis.

Lung cancer is a leading cause of cancer mortality, yet early diagnosis remains difficult, highlighting the need for sensitive, noninvasive methods. Extracellular vesicles (EVs) and their surface proteins (e.g., PD-L1) are promising biomarkers; nevertheless, current EV detection requires time-consuming purification, sophisticated instrumentation...

#6 [13.0] CRISPR/Cas13a-Regulated SERS Biosensor Based on Plasmonic-Enhanced Magnetic Rods with Intensified Electromagnetic Field Generation for Breast Cancer Associated miRNA Detection

Abstract Early and sensitive detection of breast cancer biomarkers is essential for improving patient prognosis, yet rapid and amplification-free analysis of low-abundance circulating miRNAs remains challenging. Herein, we report a CRISPR/Cas13a-regulated surface-enhanced Raman scattering (SERS) biosensor, termed the CaRER sensor, for on-site de...

#7 [13.0] Engineering of magnetic peroxidase-like heterojunction nanozymes from homogeneous iron precursor by surface-initiated encapsulation for self-calibration colorimetric/fluorescence dual-mode analysis of Hg(2 +) ion in foods.

The engineering of multi-modal optical sensors with improved detection accuracy is still a hot topic. Herein, the homologous heterostructured nanozyme with enhanced peroxidase (POD)-like activity was prepared by surface-initiated encapsulation of porphyrin-based metal-organic frameworks on magnetic ferroferric oxide (Fe3O4@TCPP-Fe) for self-cali...

#8 [12.8] An Integrated Cascade-Amplified Microfluidic Biosensor for Reconfigurable Profiling of CRC-Associated Faecal Extracellular Vesicle Surface Proteins.

Faecal extracellular vesicles (EVs) provide disease-relevant molecular information for non-invasive colorectal cancer (CRC) analysis. However, sensitive EV surface protein profiling remains challenging because low-abundance targets are obscured by heterogeneous vesicles and complex matrices. Here, an integrated cascade-amplified microfluidic bio...

#9 [12.7] Scaffold RNA Reengineering for a Leakage‐Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics

ABSTRACT Amplification‐free CRISPR detection has attracted significant attention for its capacity to circumvent the intricacies of nucleic acid amplification. Yet, the persistent challenge of high background signals remains a critical bottleneck, motivating intensive efforts toward background suppression strategies. Here, we present a 3’‐end DNA...

#10 [12.6] Molecular recognition elements-integrated multimodal nanosensing of aflatoxin B1: design principles and self-calibrating paradigms.

Aflatoxin B1 (AFB1) is a potent hepatocarcinogenic mycotoxin that poses severe health risks through contaminated agricultural products. Rapid, sensitive, reliable, and field-deployable detection methods are therefore critical for food safety. Conventional instrumental techniques suffer from high cost, complex operation, and unsuitability for on-...

Methodology