Top aptamer papers on infectious disease — updated daily
The 20 highest-scoring aptamer papers on infectious disease, ranked by the formula below and rebuilt every day. Drawn from 115 matching papers (out of 2396 in the aptamer corpus) published 2026-05-12 to 2026-09-28 across 87 journals.
按下方公式排序的 infectious disease 方向高分适配体论文，每日重建。取自语料中命中该主题的 115 篇（全库 2396 篇），发表于 2026-05-12 至 2026-09-28，涉及 87 个期刊。
Highest-scoring papers · 高分论文
-
Live imaging and interactome analysis of Zika and chikungunya viral RNAs via dual-action aptamer tag
Arthropod-borne, positive-sense RNA viruses encompass many human pathogens posing significant health threats worldwide. Understanding intracellular dynamics and host-factor interactions of the viral genome is essential for devising effective antiviral strategies. Here, we engineer dual-labeled Zika and chikungunya…
-
A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing
Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR…
-
RPA-CRISPR/Cas12a and Aptamer-Based Electrochemical Biosensing Duplex Platform for On-Site Monitoring of Antimicrobial Resistance in Water
Abstract Monitoring antimicrobial resistance (AMR) in aquatic systems is essential for tracking resistance mechanisms and identifying microbial sources. Here, we present a dual-module electrochemical sensing platform that integrates a gold-electrode-based RPA–CRISPR/Cas12a biosensor for detecting antibiotic resistance…
-
Streptavidin-Displaying E. coli Scaffolds Enable Target-Mediated Gold Nanoparticle Assembly for Colorimetric Biosensing
Enhancing the visual detection sensitivity of point-of-care (POC) optical sensors without resorting to complex, multistep chemical or enzymatic signal amplification remains a major challenge in sensor nanotechnology. Here, we present a multifunctional bio-nanostructured hybrid platform that integrates engineered…
-
Atomically dispersed ruthenium on magnetic layered double hydroxide nanozyme for a multi-mode aptasensor enabling highly sensitive kanamycin detection
Kanamycin residues in food pose health risks due to their ototoxicity, nephrotoxicity, and antimicrobial resistance promotion. This work reports a multi-mode aptasensor combining atomically dispersed ruthenium-doped magnetic layered double hydroxide (RuSA/MLDH) with exonuclease I-assisted amplification. RuSA/MLDH…
-
Peptide-Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives
Malaria and leishmaniasis continue to impose a substantial health burden, while current therapeutic and diagnostic strategies remain limited by toxicity, prolonged regimens, drug resistance, and restricted field applicability. This review examines recent advances in peptide-enabled nanoplatforms for both diseases,…
-
ZnO-based nanostructures at the biological interface: a review of bioreceptor coupling for healthcare diagnostics and therapeutics
Zinc oxide (ZnO) nanostructures are a highly versatile class of solid-state materials with functional utility in bio-interfacial architectures, governed by the coordination chemistry of surface Zn(II) sites. Bridging the gap between inorganic nanoplatforms and complex biological environments requires a sophisticated…
-
High-fidelity genotyping and therapeutic oligonucleotides analysis by liquid-phase ion trap coupled with mass spectrometry
Rapid and accurate nucleic acid analysis is essential for disease diagnostics and drug development, yet persistent metal cation interference severely limits mass spectrometry’s effectiveness. We developed a liquid-phase ion trap (LPIT) system that utilizes strong electric fields to simultaneously dissociate metal…
-
Harmonizing amplification and cleavage kinetics through crRNA scaffold mutation enables robust one-pot CRISPR–Cas12 diagnostics
CRISPR-based diagnostics (CRISPR-Dx) integrated with isothermal nucleic acid amplification have emerged as a promising strategy for point-of-care molecular testing. Their practical deployment, however, remains constrained by workflow-related limitations. Conventional two-step formats are laborious and highly…
-
Disease Biomarker Detection Using Fluorescence Polarization Assays: Principles and Clinical Applications
Modern clinical diagnostics require highly sensitive, rapid, and technologically simple methods for quantitatively determining biomarkers directly at the patient's bedside. Fluorescence polarization (FP) meets these criteria, as it enables the homogeneous recording of an analytical signal based on changes in the…
-
Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1
A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes.…
-
An interface-engineered signal-on electrochemical aptasensor for H5N2 avian influenza virus detection
Outbreaks of avian influenza virus (AIV) cause substantial economic losses in the poultry industry, highlighting the need for sensitive, reliable and field-adaptable detection platforms. In this study, we report a signal-on electrochemical aptasensor for avian influenza virus H5N2(K08-404) by translating a previously…
-
Strategies for biofilm disruption: Mechanisms, polymeric networks, mixed infections, and emerging biomaterials
Biofilms represent the predominant microbial lifestyle in clinical and environmental settings, where the extracellular polymeric substance (EPS) matrix provides structural integrity, metabolic cooperation, and pronounced antimicrobial tolerance. This matrix forms a dynamic macromolecular network of polysaccharides,…
-
High-Throughput On-Chip Screening Enables Rapid Adaptation of DNA Aptamers to SARS-CoV-2 Evolution
Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10-12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to…
-
Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA
Functional DNA nanoassemblies (fDns) hold promise for biomedical and translational applications, but broader deployment is limited by manufacturing barriers that constrain scalability, reproducibility, and stability. Current biosynthetic approaches rely heavily on downstream enzymatic processing and purification,…
- Triplex-helix molecular beacon-enabled CRISPR/Cas12a biosensor for sensitive detection of SARS-CoV-2
-
Signatures of the neutralizing dengue virus-reactive memory B cell repertoire identified by multiplexed envelope dimer probes
Sequential dengue virus (DENV) infection is thought to induce long-lived protection against dengue. However, little is known about the specificity, phenotype, and repertoire of the enduring B cell response due to limitations in high-throughput methods. We used stabilized DENV envelope (E) dimers as probes for in-depth…
-
Surface-confined CRISPR-Cas12a biosensor with metal-enhanced fluorescence for rapid and ultrasensitive detection of SARS-CoV-2 nucleocapsid protein
CRISPR-Cas12a integrated with nanomaterials has formulated powerful biosensors for viral protein detection, addressing the urgent need for point-of-care diagnostics. However, existing platforms are hindered by either multi-step separation procedures or insufficient signal amplification, limiting their sensitivity and…
-
Functionalized carbon nanotube-assisted dual-mode CRISPR/Cas12a detection of hepatitis C virus via catalytic assembly circuit-driven Y-shaped dsDNA activators
Hepatitis C virus (HCV) is a major etiological agent of liver diseases and remains a serious global health threat. Herein, we report a dual-modal HCV biosensing platform for ultrasensitive HCV RNA detection by integrating near-infrared fluorescence and colorimetric readouts. In this system, the presence of HCV RNA…
-
A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring
Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with biomarker potential. This study identifies EV-miR-107 as a candidate host-response…
How this list is built · 这份榜单怎么来的
Sources. PubMed, OpenAlex and bioRxiv are polled daily for aptamer-related publications; records are de-duplicated by DOI.
Topic filter. A paper enters this list when its title or abstract matches any of: SARS-CoV-2, COVID*, influenza, HIV, HBV, HCV, tuberculosis, Mycobacterium, Ebola, Zika, Dengue, bacterial infect*, viral infect*, pathogen detect*, antimicrobial, antibiotic resist* (SQLite FTS5, case-insensitive, * is a prefix wildcard). A paper can belong to several topics.
Ranking. composite = 0.45×log(IF) + 0.35×log(citation velocity) + 0.10×social + 0.10×recency, scaled to 100. Citation velocity is citations per day since publication, so a recent paper accruing citations quickly can outrank an older one with a larger total. The recency term decays linearly to zero at 30 days, so anything older than a month is ranked on impact and citation velocity alone — this list therefore tilts towards recent work by design.
What this is not. The ranking is computed from metadata — journal impact factor, citation counts, recency — not from reading the papers. It is a triage aid for deciding what to read, not a quality judgement or a substitute for a systematic review. Impact factor is missing for some venues (preprints in particular) and those papers score lower than their content may deserve.
这份榜单由元数据算出——期刊影响因子、引用数、时效性——而不是通过阅读论文得到。它是决定「先读哪篇」的分诊工具，不是质量判断，也不能替代系统综述。部分来源（尤其预印本）没有影响因子，其得分会低于内容应得的水平。
Where these papers appear · 语料期刊分布
| Journal | Papers | IF |
|---|---|---|
| bioRxiv (Cold Spring Harbor Laboratory) | 7 | — |
| Zenodo (CERN European Organization for Nuclear Research) | 6 | — |
| ACS sensors | 4 | 8.2 |
| ACS Sensors | 3 | 8.2 |
| Biosensors & bioelectronics | 2 | 10.7 |
| Analytical Chemistry | 2 | 6.7 |
| eLife | 2 | 6.4 |
| International journal of molecular sciences | 2 | 5.0 |
Daily archive · 每日归档（30 期）
- 2026-10-01
- 2026-09-30
- 2026-09-29
- 2026-09-28
- 2026-09-27
- 2026-09-26
- 2026-09-25
- 2026-09-24
- 2026-09-23
- 2026-09-22
- 2026-09-21
- 2026-09-20
- 2026-09-19
- 2026-09-18
- 2026-09-17
- 2026-09-16
- 2026-09-15
- 2026-09-14
- 2026-09-13
- 2026-09-12
- 2026-09-11
- 2026-09-10
- 2026-09-09
- 2026-09-08
- 2026-09-07
- 2026-09-06
- 2026-09-05
- 2026-09-04
- 2026-09-03
- 2026-09-02