Aptamer 学术简报 — infectious_disease — 2026-11-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 11 篇命中（aptamer 池 207 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [11.8] Aptamer-Functionalized Pro-Photosensitizers for Targeted Elimination of Drug-Resistant Bacterial Biofilm Infection by Sequentially Activated Photodynamic-Antibiotic Therapy.

Drug-resistant bacterial infections seriously threaten public health, and the formation of a biofilm barrier plays an important role. Drug-resistant biofilms are difficult to remove because the penetration and specificity of traditional antimicrobial drugs are poor, and the microenvironment in the inner layer of biofilms is hypoxic. Herein, we d...

#2 [11.5] Structure-Guided Optimization of a LipL32-Targeting DNA Aptamer through Molecular Dynamics and Free-Energy Analysis.

Accurate detection of leptospirosis requires high-affinity recognition of the conserved LipL32 biomarker. Although LipL32-targeting DNA aptamers have been identified through systematic evolution of ligands by exponential enrichment (SELEX), the molecular basis of their target recognition remains unclear, limiting rational post-SELEX optimization...

#3 [11.2] Dual-aptamer magnetic capture and electrochemical detection of influenza B and respiratory syncytial viruses in artificial saliva.

Saliva is a promising non-invasive specimen for respiratory virus diagnostics but its biochemical complexity challenges direct interfacing with affinity-based biosensors. We report a dual-aptamer magnetic-capture electrochemical assay for detection of influenza B virus (IBV) and human respiratory syncytial virus (hRSV) in artificial saliva. For ...

#4 [8.7] Computationally Guided Cannabinoid Discovery for Antiviral and Anticancer Applications: Chemical Space, Molecular Modeling, and Artificial Intelligence

Cannabinoids represent a structurally diverse class of molecules with potential applications in antiviral and anticancer drug discovery. However, their conformational flexibility, polypharmacology, physicochemical limitations, and heterogeneous biological effects complicate the identification of therapeutically relevant candidates. This review e...

#5 [8.7] A lifetime with RNA: John J. Rossi and the questions that science revisits.

Dr. John J. Rossi's scientific career has unfolded alongside the transformation of RNA from a biological intermediary into a programmable therapeutic modality. Beginning with catalytic RNA and anti-HIV ribozymes, his work progressed through RNA interference, expressed siRNA and shRNA, combinatorial RNA gene therapy, and aptamer-guided delivery. ...

#6 [8.3] CRISPR/Cas12-powered electrochemical biosensor for chikungunya virus DNA detection using gold-modified screen-printed carbon electrodes

Background and purpose: Chikungunya virus (CHIKV) remains a health concern because its symptoms overlap with dengue and Zika, often leading to misdiagnosis. Conventional diagnostic methods, including viral isolation, enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR), are time-consuming, costly...

#7 [8.3] Aptamer-Targeted PLGA Nanoparticles for Biofilm-Directed Intra-articular Antibiotic Delivery in Prosthetic Joint Infection

Introduction: Prosthetic joint infection (PJI) is a severe complication of orthopedic surgery, driven by biofilm-forming bacteria such as Staphylococcus aureus. Conventional antibiotics are limited in penetrating biofilms or remaining localized at the infection site. We engineered a targeted nanocarrier system by conjugating DNA aptamers specifi...

#8 [8.0] Aptamers for precision diagnosis and therapy for viral infections and parasitic neglected tropical diseases

Parasitic and viral pathogens impose a significant global health burden. Early, accurate, and affordable diagnostics remain scarce, as do therapeutics that provide a sterile cure. To address these burdens, aptamers have been proposed as potential alternatives. They offer enhanced stability through conformational modulation, cost-effectiveness, s...

#9 [8.0] Rapid and sensitive on-chip microcapillary electrophoresis for discrete SARS-CoV-2 immunocomplex diagnostics

Rapid, sensitive, and quantitative molecular diagnostics remain in sustained demand, driving the development of miniaturized analytical platforms. Conventional rapid antigen tests rely on lateral-flow techniques, requiring capture and detection antibodies, gold nanoparticle labels, and precise binding kinetics to generate a visible signal. Micro...

Methodology