Aptamer 学术简报 — therapeutic — 2026-10-15

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 62 篇命中（aptamer 池 204 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.2] Beyond SELEX: AI-driven aptamers from sequence to structure to function.

Conventional aptamer discovery by systematic evolution of ligands by exponential enrichment (SELEX) is often constrained by limited library capacity, PCR bias, and multi-round screening. The recent convergence of artificial intelligence with aptamer development is driving a paradigm shift from empirical screening toward rational, data-driven des...

#2 [14.0] Smart Oral Capsule with a Closed-Loop Sense-Decide-Act Strategy for Colitis Therapy.

Current treatments for inflammatory bowel disease (IBD) lack real-time inflammatory monitoring and lesion-specific drug delivery, resulting in poor efficacy and systemic toxicity. To address this, we present a smart oral capsule that operates a closed-loop "sense-decide-act" strategy entirely autonomously-sensing and drug release are driven by c...

#3 [13.8] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells ...

#4 [13.1] Chemical Reaction Driven Photoelectrochemical and Colorimetric Dual‐Mode Biosensing: A Label‐Free Strategy for Adenosine Deaminase Detection Based on IDIC‐4Cl

ABSTRACT Photoelectrochemical (PEC) sensing offers high sensitivity and rapid response, but its broader bioanalytical utility is constrained by the lack of intrinsic molecular recognition in most photoactive materials. Here, we present the non‐fullerene acceptor (NFA) IDIC‐4Cl as a chemically addressable photoactive material that integrates chem...

#5 [12.6] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#6 [12.6] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#7 [12.5] Lab on fiber: A 3D-printed fiber-tip microprobe for synchronous detection of doxorubicin concentration and temperature.

Accurate monitoring of doxorubicin (DOX) is important for individualized chemotherapy, yet conventional fiber-optic surface plasmon resonance (SPR) sensors are often limited by large probe dimensions and temperature cross-sensitivity. In this paper, a compact fiber-tip microprobe that integrates SPR and Fabry-Perot interference (FPI) for synchro...

#8 [11.9] Acid-Activatable Rolling Circle Replication-Based Nucleic Acid Nano-Prodrug for Combined Gene Therapy of Pancreatic Cancer.

Nucleic acid-based gene therapeutics hold great potential for precisely treating pancreatic ductal adenocarcinoma (PDAC), yet their clinical translation remains challenged by the lack of efficient delivery platforms capable of simultaneously minimizing payload leakage, intrinsic toxicity, and immunogenicity. Herein, we report an acid-activatable...

#9 [11.7] Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients.

Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug-induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (ECL) aptasensor for the detection of cardiac troponin I (cTnI) based on a two...

#10 [11.7] NIR-II-Accelerated 2D-on-2D Silicene/MOF Heterointerfaces Disrupt Tumor Redox Homeostasis for Targeted Ferroptosis

Abstract Catalytic ferroptosis therapy provides an attractive approach for tumor treatment, but its practical efficacy is often limited by insufficient reaction kinetics and the strong redox buffering capacity of the tumor microenvironment. Herein, we report an interface-engineered 2D-on-2D catalytic nanoplatform, SNs/FTC@Apt-P (SFTCP), construc...

Methodology