Aptamer 学术简报 — therapeutic — 2026-10-10

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 65 篇命中（aptamer 池 209 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.8] Chemical Reaction Driven Photoelectrochemical and Colorimetric Dual‐Mode Biosensing: A Label‐Free Strategy for Adenosine Deaminase Detection Based on IDIC‐4Cl

ABSTRACT Photoelectrochemical (PEC) sensing offers high sensitivity and rapid response, but its broader bioanalytical utility is constrained by the lack of intrinsic molecular recognition in most photoactive materials. Here, we present the non‐fullerene acceptor (NFA) IDIC‐4Cl as a chemically addressable photoactive material that integrates chem...

#2 [14.2] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#3 [14.2] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#4 [14.1] Lab on fiber: A 3D-printed fiber-tip microprobe for synchronous detection of doxorubicin concentration and temperature.

Accurate monitoring of doxorubicin (DOX) is important for individualized chemotherapy, yet conventional fiber-optic surface plasmon resonance (SPR) sensors are often limited by large probe dimensions and temperature cross-sensitivity. In this paper, a compact fiber-tip microprobe that integrates SPR and Fabry-Perot interference (FPI) for synchro...

#5 [13.5] Acid-Activatable Rolling Circle Replication-Based Nucleic Acid Nano-Prodrug for Combined Gene Therapy of Pancreatic Cancer.

Nucleic acid-based gene therapeutics hold great potential for precisely treating pancreatic ductal adenocarcinoma (PDAC), yet their clinical translation remains challenged by the lack of efficient delivery platforms capable of simultaneously minimizing payload leakage, intrinsic toxicity, and immunogenicity. Herein, we report an acid-activatable...

#6 [13.3] Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients.

Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug-induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (ECL) aptasensor for the detection of cardiac troponin I (cTnI) based on a two...

#7 [13.0] Double-Lock Superpolymer TDN is Used for the Theranostics of HCC

Abstract Hepatocellular carcinoma (HCC) is difficult to diagnose early and treat effectively due to its heterogeneity and lack of highly specific biomarkers. Here, we develop a double-lock superpolymer tetrahedral DNA (TDN) integrated with small extracellular vesicles (SUPDIA) for HCC theranostics. The TDN incorporates an HSP70 aptamer and a miR...

#8 [12.0] Next-generation electrochemical sensors for opioid detection: from nanostructured interfaces towards real-time clinical monitoring.

The increasing prevalence of opioid misuse, substance abuse, and drug addiction, and the rapid emergence of highly potent synthetic analogues have intensified the demand for rapid, sensitive and decentralized analytical technologies for opioid monitoring in public healthcare. Conventional laboratory-based methods, although highly accurate, are o...

#9 [11.8] Bifunctional Nanozymes for Synergistic Treatment by Boosting Oxidative Stress and Regulating the Protein Kinase B Pathway.

Chemoresistance and dose-limiting toxicity remain major challenges in cancer chemotherapy, largely driven by aberrant activation of the protein kinase B (AKT) survival pathway. Although small-molecule AKT inhibitors can enhance chemosensitivity, their systemic activity frequently disrupts normal metabolic processes and causes severe side effects...

#10 [11.8] Synthesis and Characterization of Aminooxy Click Chemistry-Mediated Bis -Conjugates of siRNAs and Evaluation of Their RNAi Activity

Abstract Previously, we used an aminooxy click chemistry (AOCC) strategy to introduce pairs of ligands into oligonucleotides during solid-phase synthesis by using nucleoside and non-nucleoside building blocks. However, the standard oligonucleotide synthesis conditions were incompatible with the incorporation of certain complex ligands. In this r...

Methodology