Aptamer 学术简报 — therapeutic — 2026-10-09

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 61 篇命中（aptamer 池 206 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.6] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#2 [14.6] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#3 [13.9] Acid-Activatable Rolling Circle Replication-Based Nucleic Acid Nano-Prodrug for Combined Gene Therapy of Pancreatic Cancer.

Nucleic acid-based gene therapeutics hold great potential for precisely treating pancreatic ductal adenocarcinoma (PDAC), yet their clinical translation remains challenged by the lack of efficient delivery platforms capable of simultaneously minimizing payload leakage, intrinsic toxicity, and immunogenicity. Herein, we report an acid-activatable...

#4 [13.7] Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients.

Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug-induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (ECL) aptasensor for the detection of cardiac troponin I (cTnI) based on a two...

#5 [13.3] Double-Lock Superpolymer TDN is Used for the Theranostics of HCC

Abstract Hepatocellular carcinoma (HCC) is difficult to diagnose early and treat effectively due to its heterogeneity and lack of highly specific biomarkers. Here, we develop a double-lock superpolymer tetrahedral DNA (TDN) integrated with small extracellular vesicles (SUPDIA) for HCC theranostics. The TDN incorporates an HSP70 aptamer and a miR...

#6 [12.4] Next-generation electrochemical sensors for opioid detection: from nanostructured interfaces towards real-time clinical monitoring.

The increasing prevalence of opioid misuse, substance abuse, and drug addiction, and the rapid emergence of highly potent synthetic analogues have intensified the demand for rapid, sensitive and decentralized analytical technologies for opioid monitoring in public healthcare. Conventional laboratory-based methods, although highly accurate, are o...

#7 [12.2] Bifunctional Nanozymes for Synergistic Treatment by Boosting Oxidative Stress and Regulating the Protein Kinase B Pathway.

Chemoresistance and dose-limiting toxicity remain major challenges in cancer chemotherapy, largely driven by aberrant activation of the protein kinase B (AKT) survival pathway. Although small-molecule AKT inhibitors can enhance chemosensitivity, their systemic activity frequently disrupts normal metabolic processes and causes severe side effects...

#8 [12.2] Synthesis and Characterization of Aminooxy Click Chemistry-Mediated Bis -Conjugates of siRNAs and Evaluation of Their RNAi Activity

Abstract Previously, we used an aminooxy click chemistry (AOCC) strategy to introduce pairs of ligands into oligonucleotides during solid-phase synthesis by using nucleoside and non-nucleoside building blocks. However, the standard oligonucleotide synthesis conditions were incompatible with the incorporation of certain complex ligands. In this r...

#9 [11.5] Aptamer-based discovery of MARK2 as a potential biomarker for targeted imaging and exosome detection of metastatic colorectal cancer.

Metastatic colorectal cancer (CRC) has a high recurrence rate, rapid progression and poor prognosis. Therefore, the discovery of metastatic related biomarkers is crucial for early diagnosis and treatment. Aptamer W14 was previously developed through cell-systematic evolution of ligands by exponential enrichment (SELEX), which could specifically ...

#10 [11.3] Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma.

Therapeutic strategies for glioblastoma have progressed considerably over recent decades. Despite the development of new biomedical technologies and advances in our understanding of physiology and disease progression, effective drug delivery to brain cancer remains a significant challenge. The challenge is delivering therapeutics to the correct ...

Methodology