Aptamer 学术简报 — therapeutic — 2026-09-15

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 65 篇命中（aptamer 池 225 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.8] Highly specific aptamer-based structure-switching sensor for detection of the smallest alkali metal ion Li(+) in serum.

Lithium carbonate, a frontline drug for bipolar disorder (BD), requires strict therapeutic drug monitoring (TDM) due to its narrow therapeutic window (0.6-1.2 mM). Existing methods like inductively coupled plasma mass spectrometry (ICP-MS) and ion-selective electrodes (ISE) struggle to balance point-of-care testing (POCT) demands with interferen...

#2 [14.0] Self-Assembled Aptamer-Derived PROTAC Enables Efficient Cellular Internalization for Intracellular Sclerostin Degradation and Triple-Negative Breast Cancer Therapy.

Comprising an aptamer for protein of interest (POI) recognition, a linker, and an E3 ligand, aptamer-derived PROTAC enables precise intracellular POI degradation via ubiquitin-proteasome system. Due to hydrophilic polyanionic backbone, their efficacy was fundamentally constrained by inefficient cellular internalization. Here, we engineered a sel...

#3 [13.3] Self-Enhancing Photodynamic / Immunotherapy via a MOF Nanoplatform for Combined STING Activation and Immune Checkpoint Blockade.

Combinational photodynamic and immune checkpoint blockade (PDT/ICB) therapy is a promising approach for oncotherapy. However, the tumor microenvironment (TME) poses multiple biological barriers that can critically undermine the treatment outcomes of PDT/ICB. To this end, a cascade-amplified photodynamic immunotherapy nanoplatform based on the co...

#4 [12.9] SOLiD-MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA.

RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approaches for detecting ligand-RNA interactions have provided powerful foundations, yet many rely on direct cross-linking or covalent-capture chemistries w...

#5 [12.1] Mammalian therapeutic riboswitches: Engineering and custom ligands.

Regulation with riboswitches, which induce or repress gene expression in response to a ligand, is moving from proof-of-concept studies to robust clinical-grade gene therapies. These initial stages in RNA-based precision medicine will soon benefit from the next generation of riboswitches, whose engineering results from the combination of deep lea...

#6 [11.8] Identification of melanotransferrin (MFI2) as a membrane target and an MFI2-directed aptamer as a theranostic tool for pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and limited targeted therapeutic options. Melanotransferrin (MFI2) is a membrane-anchored protein that we found to be significantly upregulated in PDAC tissues and cell lines. MFI2 knockdown markedly reduced cell proliferation, migration, invasion, and epithelial-mesenchy...

#7 [11.7] Aptamer-Functionalized DNA Frameworks as Targeted Drug Buffers for Concentration Regulation of Maytansine.

Traditional chemotherapy often suffers from nonspecific distribution and poor drug concentration control, leading to compromised therapeutic efficacy and adverse effects. Mertansine (DM1), a potent cytotoxic agent with poor selectivity, dose-limiting toxicity, and a narrow therapeutic window, demands targeted delivery and precise concentration r...

#8 [11.7] Folic acid-anchored liposomes in cancer therapy: a next-generation nanoplatform for precision drug delivery and tumor targeting.

Targeted drug delivery (TDD) has emerged as a potential strategy for cancer management by selectively delivering therapeutic agents directly to the targeted site. The current trends in TDD for cancer therapy, focus on the use of various ligands, such as hyaluronic acid, folic acid (FA), carbohydrates, peptides, antibodies, and aptamers to enhanc...

#9 [11.0] A Label-Free Graphene Quantum Dot-Based Fluorescent Aptasensor for Rapid and Sensitive Detection of Leptospira interrogans.

Leptospirosis is a neglected tropical disease that is widespread in tropical and subtropical regions. The lack of rapid and sensitive diagnostic tools continues to limit the early identification of the disease. In this study, a graphene quantum dots-based aptasensor was developed for the detection of Leptospira interrogans. Graphene quantum dots...

#10 [11.0] Small-Molecule-Directed RNA Modification via Proximity-Driven Catalysis.

Selective chemical modification of RNA is essential for RNA functionalization, probing RNA structure-function relationships and developing RNA-targeted therapeutics. Existing chemical strategies often rely on guanine accessibility or multiple helper DNA strands, restricting their generality and biological applicability. Inspired by DNA-guided DM...

Methodology