Aptamer 学术简报 — therapeutic — 2026-08-31

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 52 篇命中（aptamer 池 182 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.5] A Receptor-Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF-α Degradation for Sustained Treatment of Mucosal Inflammation.

Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF-α-mediated immune-epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although extracellular protein degradation (eTPD)...

#2 [13.0] A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA-based gene silencing, where off-target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual-AND logic gates, which enables the development of a spatiotemporally controll...

#3 [12.8] Highly sensitive galectin-3 electrochemical sensor based on a dual-recognition interface of cyclodextrin-integrated molecularly imprinted polymers (MIPs) and an aptamer.

Heart failure (HF) is a major global health burden, and elevated serum levels of galectin-3 (Gal3) are widely recognized as a reliable biomarker of disease progression. Accurate detection of Gal3 is vital for prognosis and effective management of HF. This study develops a dual-recognition sandwich sensor for Gal3, providing a sensitive and selec...

#4 [12.0] Advances in Extracellular Vesicle-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis

As a noninvasive liquid biopsy approach, extracellular vesicle (EV)-based detection offers significant advantages in reflecting real-time tumor dynamis and overcoming the limitations of conventional tissue biopsy. EVs, nanoscale vesicles secreted by cells, carry diverse biomolecules such as proteins and nucleic acids, playing key roles in tumor ...

#5 [11.9] Antibodies and aptamers as affinity ligands for exosome isolation, detection, and targeted delivery: A review.

Exosomes, key mediators of intercellular communication, are emerging as promising tools for disease diagnosis and therapy. Realizing this potential depends on technologies that can isolate, detect, and deliver exosomes with high specificity and efficiency. Affinity-based strategies that exploit the molecular recognition of antibodies and aptamer...

#6 [11.7] Selection of DNA Aptamers for Mycophenolic Acid and Mycophenolate Mofetil Detection in Human Serum.

Therapeutic drug monitoring of mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is clinically important due to its narrow therapeutic window. In this work, a library-immobilized SELEX strategy was employed to isolate DNA aptamers capable of recognizing both MPA and MMF. Among the selected candi...

#7 [11.1] A bioelectronic interface for continuous neuroinflammation monitoring and neuromodulation in Parkinson's disease model.

Neuroinflammation is increasingly recognized as a critical driver in the onset and progression of Parkinson's disease (PD), yet technologies capable of continuously tracking neuroinflammatory dynamics in vivo remain limited. Here, we report an implantable bioelectronic interface that integrates multiplexed aptamer based electrochemical biosensin...

#8 [10.8] Targeting angiogenesis: advances in the design and engineered applications of nanobodies

Angiogenesis is a fundamental physiological process; however, its pathological dysregulation drives diseases such as solid tumors, wet age-related macular degeneration, and rheumatoid arthritis. Although clinically effective, conventional anti-angiogenic monoclonal antibodies are limited by poor tissue penetration, off-target toxicities, and sus...

#9 [10.8] Surface engineered nitrogen doped carbon quantum dots for mechanistic understanding and advanced biosensing of antibiotic contaminants: a review.

Nitrogen-doped carbon quantum dots (N-CQDs) have emerged as a versatile platform for antibiotic biosensing, yet the field has been hindered by empirical optimization without mechanistic understanding. This review establishes quantitative structure-property-performance relationships that enable rational sensor design. We demonstrate that surface ...

#10 [10.8] Facile Siderophore Assembly Enables Bacterial Delivery of Nucleic Acid Therapeutics

Antibiotic resistance is an increasing threat to modern medicine that calls for the discovery of new antibiotics. RNA targeting is a promising approach for antibiotic development. In particular, antisense antibiotics, dubbed ASObiotics, are an exciting class of oligomers that show promise as powerful antibiotic agents. However, limited bacterial...

Methodology