Aptamer 学术简报 — therapeutic — 2026-08-26

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 54 篇命中（aptamer 池 196 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.7] A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA-based gene silencing, where off-target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual-AND logic gates, which enables the development of a spatiotemporally controll...

#2 [14.0] Facile Siderophore Assembly Enables Bacterial Delivery of Nucleic Acid Therapeutics

Antibiotic resistance is an increasing threat to modern medicine that calls for the discovery of new antibiotics. RNA targeting is a promising approach for antibiotic development. In particular, antisense antibiotics, dubbed ASObiotics, are an exciting class of oligomers that show promise as powerful antibiotic agents. However, limited bacterial...

#3 [13.6] Antibodies and aptamers as affinity ligands for exosome isolation, detection, and targeted delivery: A review.

Exosomes, key mediators of intercellular communication, are emerging as promising tools for disease diagnosis and therapy. Realizing this potential depends on technologies that can isolate, detect, and deliver exosomes with high specificity and efficiency. Affinity-based strategies that exploit the molecular recognition of antibodies and aptamer...

#4 [12.8] A bioelectronic interface for continuous neuroinflammation monitoring and neuromodulation in Parkinson's disease model.

Neuroinflammation is increasingly recognized as a critical driver in the onset and progression of Parkinson's disease (PD), yet technologies capable of continuously tracking neuroinflammatory dynamics in vivo remain limited. Here, we report an implantable bioelectronic interface that integrates multiplexed aptamer based electrochemical biosensin...

#5 [12.5] Targeting angiogenesis: advances in the design and engineered applications of nanobodies

Angiogenesis is a fundamental physiological process; however, its pathological dysregulation drives diseases such as solid tumors, wet age-related macular degeneration, and rheumatoid arthritis. Although clinically effective, conventional anti-angiogenic monoclonal antibodies are limited by poor tissue penetration, off-target toxicities, and sus...

#6 [12.4] Surface engineered nitrogen doped carbon quantum dots for mechanistic understanding and advanced biosensing of antibiotic contaminants: a review.

Nitrogen-doped carbon quantum dots (N-CQDs) have emerged as a versatile platform for antibiotic biosensing, yet the field has been hindered by empirical optimization without mechanistic understanding. This review establishes quantitative structure-property-performance relationships that enable rational sensor design. We demonstrate that surface ...

#7 [12.2] Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer-Chemotherapeutics Conjugates Based on DNA Tiling-Mediated Structural Nanotechnology.

While DNA origami nanotubes have been often used in the biomedical field, the technical challenges in the assembly at large scale and the susceptibility to degradation limit their exploration for clinical application. In the current contribution, we propose a structural DNA nanotechnology (TMM) for the construction of a degradation-resistant DNA...

#8 [11.8] High-ThroughputOn-Chip Screening Enables Rapid Adaptationof DNA Aptamers to SARS-CoV-2 Evolution

Abstract Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10–12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to keep pace with viral e...

#9 [11.4] Novel RNA aptamer HPE3 suppresses angiogenesis via inhibiting endocan–VEGF-A formation in Matrigel-implanted mice

Endocan is a vascular endothelial cell-secreted factor that is closely associated with angiogenesis and inflammation, regulates VEGF-A-mediated angiogenesis. While antibody- and siRNA-based strategies have targeted endocan, limitations in intracellular delivery and specificity have driven the development of aptamer-based therapeutics. In this st...

#10 [11.3] AptaNexus: An AI-Driven Platform for Aptamer Data Discovery and Intelligent Interaction.

Aptamers are widely used in biosensing and targeted therapeutics, yet reported data remain fragmented across unstructured text, tables, and figures. Existing databases are limited in coverage and diversity, which constrains computational modeling. Here, we present AptaNexus (https://www.aptanexus.com/), a multitier aptamer database containing ov...

Methodology