Aptamer 学术简报 — therapeutic — 2026-08-22

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 55 篇命中（aptamer 池 182 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.1] Facile Siderophore Assembly Enables Bacterial Delivery of Nucleic Acid Therapeutics

Antibiotic resistance is an increasing threat to modern medicine that calls for the discovery of new antibiotics. RNA targeting is a promising approach for antibiotic development. In particular, antisense antibiotics, dubbed ASObiotics, are an exciting class of oligomers that show promise as powerful antibiotic agents. However, limited bacterial...

#2 [15.3] A review of exosome isolation based on membrane protein recognition: Methods, performance, and challenges.

BACKGROUND: Exosomes participate in physiological and pathological processes such as intercellular communication, immune regulation, and tumor initiation and progression, holding significant potential in early disease diagnosis, therapeutic target identification, and drug delivery system development. However, the isolation of exosomes presents s...

#3 [13.5] Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer-Chemotherapeutics Conjugates Based on DNA Tiling-Mediated Structural Nanotechnology.

While DNA origami nanotubes have been often used in the biomedical field, the technical challenges in the assembly at large scale and the susceptibility to degradation limit their exploration for clinical application. In the current contribution, we propose a structural DNA nanotechnology (TMM) for the construction of a degradation-resistant DNA...

#4 [13.2] High-ThroughputOn-Chip Screening Enables Rapid Adaptationof DNA Aptamers to SARS-CoV-2 Evolution

Abstract Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10–12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to keep pace with viral e...

#5 [12.7] AptaNexus: An AI-Driven Platform for Aptamer Data Discovery and Intelligent Interaction.

Aptamers are widely used in biosensing and targeted therapeutics, yet reported data remain fragmented across unstructured text, tables, and figures. Existing databases are limited in coverage and diversity, which constrains computational modeling. Here, we present AptaNexus (https://www.aptanexus.com/), a multitier aptamer database containing ov...

#6 [12.5] Toward an Aptamer-Based Biosensor for Cross-Serotype Detection of Botulinum Neurotoxin: Binding Mechanism from a Comprehensive Computational Investigation

Abstract Botulism is a potentially fatal illness in humans and many animals caused by the botulinum neurotoxins (BoNTs) produced mainly by Clostridium botulinum, which can be found in a wide variety of foods. The treatment of this illness requires antitoxin drugs given to the patients within a 48 h window to be effective. Therefore, there is a s...

#7 [12.3] MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion.

Organ transplantation provides a life-saving intervention for patients with end-stage lung disease; however, access to this treatment remains limited by the shortage of donor organs. Ex vivo lung perfusion (EVLP) is a platform that enables surgeons to assess extended-criteria for donor lungs prior to transplantation and has safely expanded the d...

#8 [12.3] An Au NC- andAg NP-Loaded DNA Microcapsule-BasedSystem for the Detection and Elimination of Staphylococcus aureus

Abstract Early detection and deactivation of Staphylococcus aureus (S. aureus) are of great importance to prevent pathogen-induced bacterial infectious diseases. Here, we initially synthesized stimuli-responsive DNA microcapsule coencapsulating gold nanoclusters (Au NCs) and silver nanoparticles (Ag NPs) (Au/Ag/DNA microcapsule) and, using it, d...

#9 [12.3] Programmable Electrochemical Cefapirin AntibioticAptasensor Powered by Highly Conductive Bimetallic NiCu(HITP) MOFand Dendritic DNA Amplifications

Abstract Residues of veterinary antibiotics in animal-derived foods motivate the development of analytical methods that combine high sensitivity with straightforward operation. Cefapirin, a β-lactam used extensively for the treatment of bovine mastitis, may persist in milk and other commodities; therefore, sensitive detection of trace-level cefa...

#10 [12.0] Nanopore-Based Profiling of PEGylation in Nucleic Acid Therapeutics.

Nucleic acid therapeutics (NATs), including aptamers, offer effective strategies for programmable and targeted disease treatment. To improve their stability and circulation time, oligonucleotides are often conjugated to hydrophilic polymers, such as polyethylene glycol (PEG). However, current bulk techniques fail to resolve PEG heterogeneity, es...

Methodology