Aptamer 学术简报 — therapeutic — 2026-08-13

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 60 篇命中（aptamer 池 200 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.7] A review of exosome isolation based on membrane protein recognition: Methods, performance, and challenges.

BACKGROUND: Exosomes participate in physiological and pathological processes such as intercellular communication, immune regulation, and tumor initiation and progression, holding significant potential in early disease diagnosis, therapeutic target identification, and drug delivery system development. However, the isolation of exosomes presents s...

#2 [15.9] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#3 [15.0] Nanopore-Based Profiling of PEGylation in Nucleic Acid Therapeutics.

Nucleic acid therapeutics (NATs), including aptamers, offer effective strategies for programmable and targeted disease treatment. To improve their stability and circulation time, oligonucleotides are often conjugated to hydrophilic polymers, such as polyethylene glycol (PEG). However, current bulk techniques fail to resolve PEG heterogeneity, es...

#4 [14.6] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#5 [14.1] Fabrication of electrochemical biosensor with a CD36 aptamer and AuMoS(2) heterolayer for tumor-derived exosome detection.

Breast cancer (BC), which is often diagnosed at advanced stages owing to its asymptomatic progression, presents with substantial molecular heterogeneity, leading to diverse therapeutic responses and prognostic outcomes. Among its molecular subtypes, the human epidermal growth factor receptor 2-positive/hormone receptor-negative (HER2+/HR-) pheno...

#6 [13.6] Author Correction: Therapeutic application of circular RNA aptamers in a mouse model of psoriasis.

#7 [13.3] Systematic Scanning Mutagenesis Unveils the Structure-Function Landscape Enabling Aptamer Evolution.

Aptamers are valuable recognition elements for biosensing and therapeutic applications; however, an accessible strategy to link structure with function during postselection engineering remains challenging. Here, we introduce the concept of a structure-function landscape for aptamers, constructed by systematic single-point mutagenesis that maps t...

#8 [13.3] A Fossilization-Inspired Photoelectrochemical Sensing Platform: DNA-Induced In Situ CaCO3 Crystal Growth Modulates The Photoelectrochemical Response of Gold Electrodes for Ultrasensitive Aflatoxin B1 Detection.

Although photoelectrochemical (PEC) sensing offers low background and high sensitivity, most PEC platforms rely on semiconductor materials and immobilized recognition probes, which complicate electrode fabrication and reduce operational simplicity. Herein, we report a fossilization-inspired photoelectrochemical sensing platform (FIPSP) for ultra...

#9 [13.3] A cascade-amplified Fe(3)O(4)-based nanoplatform for miRNA-21 sensing and combined apoptosis/ferroptosis induction.

A miRNA-21-responsive analytical nanoplatform based on Fe₃O₄@polydopamine (PDA) was constructed for co-delivery of doxorubicin (DOX) and functional nucleic acids, with glucose oxidase (GOx) immobilized to achieve cascade-amplified combined therapeutic effects; notably, the proposed self-supplying oxidative cascade is a proof-of-concept deduction...

#10 [13.0] Electrochemical Cytosensor with Dual-Site Recognition Fabricated by In Situ Catalase-Encapsulated Metal-Organic Frameworks for Isolation and Detection of Circulating Tumor Cells in Whole Blood.

Circulating tumor cells (CTCs) are critical biomarkers for cancer prognosis and treatment monitoring, yet their detection remains challenging due to low abundance and phenotypic heterogeneity. Herein, we developed a dual-aptamer-conjugated electrochemical cytosensor using an in situ catalase (CAT)-encapsulated nanozyme CAT@Fe(SS)MOF-EpCAM/MUC1 (...

Methodology