Aptamer 学术简报 — therapeutic — 2026-08-07

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 56 篇命中（aptamer 池 188 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [19.9] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#2 [18.6] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#3 [18.5] Fabrication of electrochemical biosensor with a CD36 aptamer and AuMoS(2) heterolayer for tumor-derived exosome detection.

Breast cancer (BC), which is often diagnosed at advanced stages owing to its asymptomatic progression, presents with substantial molecular heterogeneity, leading to diverse therapeutic responses and prognostic outcomes. Among its molecular subtypes, the human epidermal growth factor receptor 2-positive/hormone receptor-negative (HER2+/HR-) pheno...

#4 [17.1] Surface activation and functionalization with aryl-diazonium chemistry enable biomolecules grafting on 3D printed carbon-based electrodes.

Carbon-based electrodes printed using fused deposition modelling (FDM) technology constitute appealing platforms for electrochemical biosensors. However, immobilizing bioreceptors that retain their stability and recognition properties at the electrode surface is quite challenging. So far, only few successful biosensors based on covalently bindin...

#5 [15.6] Author Correction: Therapeutic application of circular RNA aptamers in a mouse model of psoriasis.

#6 [14.9] Nitro Reduction-Based RNA Control and Ultrafast Release.

RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post-synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straightforward approach based on ribose 2'-hydroxyl acylation with a nitro-functi...

#7 [13.3] AptaNexus:An AI-Driven Platform for Aptamer DataDiscovery and Intelligent Interaction

Abstract Aptamers are widely used in biosensing and targeted therapeutics, yet reported data remain fragmented across unstructured text, tables, and figures. Existing databases are limited in coverage and diversity, which constrains computational modeling. Here, we present AptaNexus (https://www.aptanexus.com/), a multitier aptamer database cont...

#8 [12.9] Aptamer screening within sample matrices: Toward reliable applications.

Nucleic acid aptamers are short oligonucleotide sequences selected in vitro by Systematic Evolution of Ligands by EXponential enrichment (SELEX). As "chemical antibodies", they recognize diverse targets with high affinity and specificity through structure-dependent interactions and offer multiple attractive features. Although a few natural aptam...

#9 [11.8] Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase‐Separation–Based Intelligent Drug Delivery

Functionalized coacervates, a type of nanomaterial inspired by biomolecular condensation, have emerged as an important research direction in biomedicine, particularly in cancer therapy. These membraneless structures formed by liquid-liquid phase separation (LLPS) self-assembly have high drug-loading capacity, favorable biocompatibility, and tuna...

#10 [11.7] Nanopore-Based Profilingof PEGylation in NucleicAcid Therapeutics

ABSTRACT Nucleic acid therapeutics, including aptamers, offer effective strategies for programmable and targeted disease treatment. To improve their stability and circulation time, oligonucleotides are often conjugated to hydrophilic polymers such as polyethylene glycol (PEG). However, current bulk techniques fail to resolve PEG heterogeneity, e...

Methodology