Aptamer 学术简报 — therapeutic — 2026-08-06

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 61 篇命中（aptamer 池 190 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [20.9] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#2 [19.6] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#3 [19.5] Fabrication of electrochemical biosensor with a CD36 aptamer and AuMoS(2) heterolayer for tumor-derived exosome detection.

Breast cancer (BC), which is often diagnosed at advanced stages owing to its asymptomatic progression, presents with substantial molecular heterogeneity, leading to diverse therapeutic responses and prognostic outcomes. Among its molecular subtypes, the human epidermal growth factor receptor 2-positive/hormone receptor-negative (HER2+/HR-) pheno...

#4 [18.1] Surface activation and functionalization with aryl-diazonium chemistry enable biomolecules grafting on 3D printed carbon-based electrodes.

Carbon-based electrodes printed using fused deposition modelling (FDM) technology constitute appealing platforms for electrochemical biosensors. However, immobilizing bioreceptors that retain their stability and recognition properties at the electrode surface is quite challenging. So far, only few successful biosensors based on covalently bindin...

#5 [15.9] Author Correction: Therapeutic application of circular RNA aptamers in a mouse model of psoriasis.

#6 [15.2] Nitro Reduction-Based RNA Control and Ultrafast Release.

RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post-synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straightforward approach based on ribose 2'-hydroxyl acylation with a nitro-functi...

#7 [13.2] Aptamer screening within sample matrices: Toward reliable applications.

Nucleic acid aptamers are short oligonucleotide sequences selected in vitro by Systematic Evolution of Ligands by EXponential enrichment (SELEX). As "chemical antibodies", they recognize diverse targets with high affinity and specificity through structure-dependent interactions and offer multiple attractive features. Although a few natural aptam...

#8 [12.2] Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase‐Separation–Based Intelligent Drug Delivery

Functionalized coacervates, a type of nanomaterial inspired by biomolecular condensation, have emerged as an important research direction in biomedicine, particularly in cancer therapy. These membraneless structures formed by liquid-liquid phase separation (LLPS) self-assembly have high drug-loading capacity, favorable biocompatibility, and tuna...

#9 [12.0] SystematicScanning Mutagenesis Unveils the Structure–FunctionLandscape Enabling Aptamer Evolution

Abstract Aptamers are valuable recognition elements for biosensing and therapeutic applications; however, an accessible strategy to link structure with function during postselection engineering remains challenging. Here, we introduce the concept of a structure–function landscape for aptamers, constructed by systematic single-point mutagenesis th...

#10 [11.8] A Wearable Extracorporeal Device for Imaging‐Guided Therapy of Sepsis Through Rapid Removal of Bacteria

ABSTRACT Sepsis is a severe infectious disease triggered by pathogenic bacteria invading the bloodstream, with mortality risk increasing by 7%–9% for each hour of delayed treatment. Real‐time pathogen monitoring and rapid intervention are crucial for the timely and effective management of sepsis. Here, we show that a wearable extracorporeal bloo...

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