Aptamer 学术简报 — therapeutic — 2026-08-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 57 篇命中（aptamer 池 183 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.1] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#2 [14.9] Aptamer screening within sample matrices: Toward reliable applications.

Nucleic acid aptamers are short oligonucleotide sequences selected in vitro by Systematic Evolution of Ligands by EXponential enrichment (SELEX). As "chemical antibodies", they recognize diverse targets with high affinity and specificity through structure-dependent interactions and offer multiple attractive features. Although a few natural aptam...

#3 [13.8] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#4 [13.8] Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase‐Separation–Based Intelligent Drug Delivery

Functionalized coacervates, a type of nanomaterial inspired by biomolecular condensation, have emerged as an important research direction in biomedicine, particularly in cancer therapy. These membraneless structures formed by liquid-liquid phase separation (LLPS) self-assembly have high drug-loading capacity, favorable biocompatibility, and tuna...

#5 [13.5] A Wearable Extracorporeal Device for Imaging‐Guided Therapy of Sepsis Through Rapid Removal of Bacteria

ABSTRACT Sepsis is a severe infectious disease triggered by pathogenic bacteria invading the bloodstream, with mortality risk increasing by 7%–9% for each hour of delayed treatment. Real‐time pathogen monitoring and rapid intervention are crucial for the timely and effective management of sepsis. Here, we show that a wearable extracorporeal bloo...

#6 [13.2] Corrigendum to "PSMA RNA aptamer A10-3.2 conjugated with indocyanine green for rapid intraoperative imaging and effective mild photothermal therapy of prostate cancer" [Int. J. Biol. Macromol. 2026 Feb; 341(Pt 2):150303].

#7 [12.8] Aptasensors for lung cancer detection.

Lung cancer is a highly prevalent and lethal malignant tumor worldwide, accounting for approximately 25% of all cancer deaths. Early symptoms are often subtle, leading to late-stage diagnosis in the majority of patients and a missed window for optimal treatment. Therefore, more sensitive diagnostic approaches are urgently required to improve sur...

#8 [12.8] EPGD co-delivery of doxorubicin and gemcitabine enhances activity in EpCAM-high tumour models with lower renal injury-associated readouts in a microfluidic co-culture platform.

Cytotoxic chemotherapy remains indispensable for many epithelial malignancies, yet gemcitabine (GEM) and doxorubicin (DOX) are constrained by a narrow therapeutic index and clinically significant toxicity. Here, we developed an epithelial cell adhesion molecule (EpCAM)-targeted DNA aptamer (EP)-based construct for co-delivery of GEM and DOX and ...

#9 [12.8] Detection of Point Mutation in Individual Living Circulating Malignant Cells by Targeting Molecular Beacon Delivery.

As a prevalent form of genetic alteration, single-base substitution serves as a critical determinant of targeted cancer therapeutic strategies and a driver of acquired drug resistance. Despite its clinical significance, detecting these mutations at the single-cell level remains challenging due to high costs, long analysis times, and difficulties...

#10 [12.5] A versatile strategy for oligonucleotide functionalization via on-support phosphitylation

Abstract Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited by challenges rel...

Methodology