Aptamer 学术简报 — therapeutic — 2026-07-29

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 56 篇命中（aptamer 池 196 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.5] A Wearable Extracorporeal Device for Imaging‐Guided Therapy of Sepsis Through Rapid Removal of Bacteria

ABSTRACT Sepsis is a severe infectious disease triggered by pathogenic bacteria invading the bloodstream, with mortality risk increasing by 7%–9% for each hour of delayed treatment. Real‐time pathogen monitoring and rapid intervention are crucial for the timely and effective management of sepsis. Here, we show that a wearable extracorporeal bloo...

#2 [13.8] Detection of Point Mutation in Individual Living Circulating Malignant Cells by Targeting Molecular Beacon Delivery.

As a prevalent form of genetic alteration, single-base substitution serves as a critical determinant of targeted cancer therapeutic strategies and a driver of acquired drug resistance. Despite its clinical significance, detecting these mutations at the single-cell level remains challenging due to high costs, long analysis times, and difficulties...

#3 [13.5] A versatile strategy for oligonucleotide functionalization via on-support phosphitylation

Abstract Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited by challenges rel...

#4 [13.5] Human Epidermal Growth Factor Receptor 2 Dynamics Regulated by Actin-Filament Integrity on Cell Membranes Revealed by Single-Nanoconstruct Tracking.

This work demonstrates that the integrity of actin filaments can selectively regulate both lateral motion and in-plane orientation of transmembrane proteins on cell membranes. Using anisotropic gold nanostars functionalized with HER2 (human epidermal growth factor receptor)-targeting aptamers as optical probes, we tracked HER2 receptor dynamics ...

#5 [13.0] Recent advances in nanozyme assisted miRNA biosensing for disease diagnosis

MiRNAs have emerged as key biomarkers for early disease detection and therapeutic monitoring; yet, their ultrasensitive and specific detection confronts challenges due to low expression levels in biological fluids and high sequence homology, therefore it demands innovative sensing strategies. Enzyme mimicking nanostructures or nanozymes, enable ...

#6 [12.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#7 [12.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#8 [12.1] Ultrafast and ultrasensitive electrochemical aptasensor for multiplexed monitoring of hemorrhagic transformation biomarker in acute ischemic stroke.

Hemorrhagic transformation (HT) remains a life-threatening complication after acute ischemic stroke (AIS), yet no active predictive tool is available for early risk assessment. Herein, we develop an integrated triplex electrochemical aptasensing platform for the parallel and simultaneous quantification of three HT-associated biomarkers-matrix me...

#9 [11.6] Threading Precision: Progress and Emerging Trends in Aptamer-Based Nanopore Sensing

In recent years, nanopore technology has enhanced analyte detection, enabled higher resolution and achieved single-molecule sensing capability. Aptamer-conjugated nanopore sensing technology combines the high specificity of aptamers with the single-molecule resolution of nanopores. By anchoring aptamers to biological, solid-state or hybrid nanop...

#10 [11.6] ETTAS: a modular aptamer-recruited platform for programmable translational activation.

Precise enhancement of endogenous protein synthesis offers a reversible therapeutic strategy without permanent genomic modification. However, existing Cas13-mediated translational activation systems are limited by modest potency and restricted modular expandability. Here, we developed the Enhanced Targeted Translational Activation System (ETTAS)...

Methodology