Aptamer 学术简报 — therapeutic — 2026-07-27

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 50 篇命中（aptamer 池 190 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.5] Detection of Point Mutation in Individual Living Circulating Malignant Cells by Targeting Molecular Beacon Delivery.

As a prevalent form of genetic alteration, single-base substitution serves as a critical determinant of targeted cancer therapeutic strategies and a driver of acquired drug resistance. Despite its clinical significance, detecting these mutations at the single-cell level remains challenging due to high costs, long analysis times, and difficulties...

#2 [14.2] A versatile strategy for oligonucleotide functionalization via on-support phosphitylation

Abstract Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited by challenges rel...

#3 [14.2] Human Epidermal Growth Factor Receptor 2 Dynamics Regulated by Actin-Filament Integrity on Cell Membranes Revealed by Single-Nanoconstruct Tracking.

This work demonstrates that the integrity of actin filaments can selectively regulate both lateral motion and in-plane orientation of transmembrane proteins on cell membranes. Using anisotropic gold nanostars functionalized with HER2 (human epidermal growth factor receptor)-targeting aptamers as optical probes, we tracked HER2 receptor dynamics ...

#4 [13.6] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#5 [13.6] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#6 [12.8] Ultrafast and ultrasensitive electrochemical aptasensor for multiplexed monitoring of hemorrhagic transformation biomarker in acute ischemic stroke.

Hemorrhagic transformation (HT) remains a life-threatening complication after acute ischemic stroke (AIS), yet no active predictive tool is available for early risk assessment. Herein, we develop an integrated triplex electrochemical aptasensing platform for the parallel and simultaneous quantification of three HT-associated biomarkers-matrix me...

#7 [12.3] Threading Precision: Progress and Emerging Trends in Aptamer-Based Nanopore Sensing

In recent years, nanopore technology has enhanced analyte detection, enabled higher resolution and achieved single-molecule sensing capability. Aptamer-conjugated nanopore sensing technology combines the high specificity of aptamers with the single-molecule resolution of nanopores. By anchoring aptamers to biological, solid-state or hybrid nanop...

#8 [12.3] ETTAS: a modular aptamer-recruited platform for programmable translational activation.

Precise enhancement of endogenous protein synthesis offers a reversible therapeutic strategy without permanent genomic modification. However, existing Cas13-mediated translational activation systems are limited by modest potency and restricted modular expandability. Here, we developed the Enhanced Targeted Translational Activation System (ETTAS)...

#9 [12.1] Smart wearable biosensors: a transformative synergy between diagnosis and treatment of disease.

Smart wearable biosensors represent a significant paradigm shift from one-time sample analysis to real-time biochemical monitoring at the body interface. Besides the flexible design of the device or wireless readout, their clinical utility will also require the reliability of the entire sensing pathway under real physiological conditions. This p...

#10 [12.0] Fluorescence-Guided Nanobomb for Triple-Action Tumor Annihilation Based on Fe/Mn Porphyrin MOFs.

Porphyrin bimetallic metal-organic frameworks (BMOFs) have promising applications in photodynamic therapy (PDT) and chemodynamic therapy (CDT) for tumor therapy. However, their therapeutic effect is restricted by the insufficient reactive oxygen species generated by BMOFs. Herein, a nanobomb, Fe-TCPP(Mn)/DOX/PEG/Apt-M (FTMDPA), with pH-responsiv...

Methodology