Aptamer 学术简报 — therapeutic — 2026-07-24

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 44 篇命中（aptamer 池 167 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.2] A versatile strategy for oligonucleotide functionalization via on-support phosphitylation

Abstract Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited by challenges rel...

#2 [15.2] Human Epidermal Growth Factor Receptor 2 Dynamics Regulated by Actin-Filament Integrity on Cell Membranes Revealed by Single-Nanoconstruct Tracking.

This work demonstrates that the integrity of actin filaments can selectively regulate both lateral motion and in-plane orientation of transmembrane proteins on cell membranes. Using anisotropic gold nanostars functionalized with HER2 (human epidermal growth factor receptor)-targeting aptamers as optical probes, we tracked HER2 receptor dynamics ...

#3 [14.6] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#4 [14.6] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#5 [13.8] Ultrafast and ultrasensitive electrochemical aptasensor for multiplexed monitoring of hemorrhagic transformation biomarker in acute ischemic stroke.

Hemorrhagic transformation (HT) remains a life-threatening complication after acute ischemic stroke (AIS), yet no active predictive tool is available for early risk assessment. Herein, we develop an integrated triplex electrochemical aptasensing platform for the parallel and simultaneous quantification of three HT-associated biomarkers-matrix me...

#6 [13.0] Fluorescence-Guided Nanobomb for Triple-Action Tumor Annihilation Based on Fe/Mn Porphyrin MOFs.

Porphyrin bimetallic metal-organic frameworks (BMOFs) have promising applications in photodynamic therapy (PDT) and chemodynamic therapy (CDT) for tumor therapy. However, their therapeutic effect is restricted by the insufficient reactive oxygen species generated by BMOFs. Herein, a nanobomb, Fe-TCPP(Mn)/DOX/PEG/Apt-M (FTMDPA), with pH-responsiv...

#7 [12.8] Biological properties of soluble CD146 and its role and mechanisms in disease progression

Soluble CD146 (sCD146) is a key circulating biomarker released from vascular endothelial cells via enzymatic cleavage under conditions of stress or activation.sCD146 not only dynamically reflects the integrity of the microvascular endothelial barrier but also profoundly drives the malignant progression of multisystem diseases through targeted in...

#8 [12.8] A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring.

Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with biomarker potential. This study identifies EV-miR-107 as a candidate host-response biomarker for TB, showing sig...

#9 [12.6] The versatile world of MXene nanohybrids: designed synthesis, functional diversity, and promising theranostics

MXenes, a rapidly expanding class of two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides (Mₙ₊₁XₙTₓ), have emerged as transformative platforms for advanced analytical and biosensing technologies because of their metallic conductivity, tunable surface terminations, and high interfacial reactivity. This review establishes a ...

#10 [12.4] Development of an RNA aptamer as a therapeutic agent for synucleinopathies.

The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodegeneration. Despite the availability of symptomatic treatm...

Methodology