Aptamer 学术简报 — therapeutic — 2026-07-23

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 49 篇命中（aptamer 池 166 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#2 [14.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#3 [14.1] Ultrafast and ultrasensitive electrochemical aptasensor for multiplexed monitoring of hemorrhagic transformation biomarker in acute ischemic stroke.

Hemorrhagic transformation (HT) remains a life-threatening complication after acute ischemic stroke (AIS), yet no active predictive tool is available for early risk assessment. Herein, we develop an integrated triplex electrochemical aptasensing platform for the parallel and simultaneous quantification of three HT-associated biomarkers-matrix me...

#4 [13.1] Biological properties of soluble CD146 and its role and mechanisms in disease progression

Soluble CD146 (sCD146) is a key circulating biomarker released from vascular endothelial cells via enzymatic cleavage under conditions of stress or activation.sCD146 not only dynamically reflects the integrity of the microvascular endothelial barrier but also profoundly drives the malignant progression of multisystem diseases through targeted in...

#5 [13.1] A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring.

Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with biomarker potential. This study identifies EV-miR-107 as a candidate host-response biomarker for TB, showing sig...

#6 [13.0] The versatile world of MXene nanohybrids: designed synthesis, functional diversity, and promising theranostics

MXenes, a rapidly expanding class of two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides (Mₙ₊₁XₙTₓ), have emerged as transformative platforms for advanced analytical and biosensing technologies because of their metallic conductivity, tunable surface terminations, and high interfacial reactivity. This review establishes a ...

#7 [12.7] Development of an RNA aptamer as a therapeutic agent for synucleinopathies.

The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodegeneration. Despite the availability of symptomatic treatm...

#8 [12.1] Hairpin fuel-driven fluorogenic DNA aptamer amplifier for high-contrast imaging of microRNAs in living cells.

The spontaneous leakage and constitutive activity of the conventional fluorescent dye-labeled entropy-driven catalytic (EDC) circuit severely compromise the accuracy of low-abundance intracellular microRNAs (miRNAs) analysis. Herein, a Hairpin fuel-Driven Fluorogenic DNA Aptamer (HDFA) amplifier has been engineered for high-contrast imaging of m...

#9 [12.1] Bifunctional fluorescent aptasensors for simultaneously monitoring multiple signaling molecules involved in cellular inflammation.

ATP and SO2, as two crucial signaling molecules, are extensively involved in various physiological and pathological processes in organisms, and also play important roles in cellular inflammation. Detecting and imaging the secreted ATP and SO2 from inflammatory cells can help monitor the inflammatory process and dynamically evaluate the effects o...

#10 [11.3] In Situ SERS Monitoring of Membrane Protein Homo- and Hetero-Dimerizations at the Single-Cell Level.

Dimerization of cell membrane receptors governs essential cellular processes─including signal transduction, growth, proliferation, and apoptosis─yet precise discrimination between homo- and heterodimers remains a persistent technical challenge. To address this, we developed an in situ surface-enhanced Raman scattering (SERS) imaging strategy tha...

Methodology