Aptamer 学术简报 — therapeutic — 2026-07-22

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 50 篇命中（aptamer 池 171 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.5] Biological properties of soluble CD146 and its role and mechanisms in disease progression

Soluble CD146 (sCD146) is a key circulating biomarker released from vascular endothelial cells via enzymatic cleavage under conditions of stress or activation.sCD146 not only dynamically reflects the integrity of the microvascular endothelial barrier but also profoundly drives the malignant progression of multisystem diseases through targeted in...

#2 [13.5] A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring.

Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with biomarker potential. This study identifies EV-miR-107 as a candidate host-response biomarker for TB, showing sig...

#3 [13.1] Development of an RNA aptamer as a therapeutic agent for synucleinopathies.

The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodegeneration. Despite the availability of symptomatic treatm...

#4 [12.5] Hairpin fuel-driven fluorogenic DNA aptamer amplifier for high-contrast imaging of microRNAs in living cells.

The spontaneous leakage and constitutive activity of the conventional fluorescent dye-labeled entropy-driven catalytic (EDC) circuit severely compromise the accuracy of low-abundance intracellular microRNAs (miRNAs) analysis. Herein, a Hairpin fuel-Driven Fluorogenic DNA Aptamer (HDFA) amplifier has been engineered for high-contrast imaging of m...

#5 [12.5] Bifunctional fluorescent aptasensors for simultaneously monitoring multiple signaling molecules involved in cellular inflammation.

ATP and SO2, as two crucial signaling molecules, are extensively involved in various physiological and pathological processes in organisms, and also play important roles in cellular inflammation. Detecting and imaging the secreted ATP and SO2 from inflammatory cells can help monitor the inflammatory process and dynamically evaluate the effects o...

#6 [11.7] In Situ SERS Monitoring of Membrane Protein Homo- and Hetero-Dimerizations at the Single-Cell Level.

Dimerization of cell membrane receptors governs essential cellular processes─including signal transduction, growth, proliferation, and apoptosis─yet precise discrimination between homo- and heterodimers remains a persistent technical challenge. To address this, we developed an in situ surface-enhanced Raman scattering (SERS) imaging strategy tha...

#7 [11.6] Nanoparticle Engineering in Modern Vaccinology: From Delivery Platforms to Immune-Programming Architectures

Recent advances in vaccinology have accelerated the shift from conventional live-attenuated and inactivated vaccines toward subunit and nucleic acid-based platforms. Although these next-generation vaccines offer improved safety, rapid adaptability, and manufacturing flexibility, their relatively low intrinsic immunogenicity often requires effici...

#8 [11.4] Development of Small Interfering RNA-Loaded Extracellular Vesicles via a High-Pressure Homogenization Approach

Extracellular vesicles (EVs) have garnered significant interest as potential bioderived drug delivery systems for RNA therapeutics owing to their distinctive characteristics, which include their inherent capability to transport various biological molecules throughout the body. However, several issues still pose challenges, such as the limited lo...

#9 [11.2] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies.

Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins, and efficiently optimizing their binding affinities, remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experimental vali...

#10 [11.2] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

Abstract Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experiment...

Methodology