Aptamer 学术简报 — therapeutic — 2026-07-15

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 94 篇命中（aptamer 池 253 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.8] High affinity and selective DNA aptamers for the detection of tobramycin in eye drops.

Tobramycin is a frontline aminoglycoside antibiotic with a narrow therapeutic window. Here, we report the selection of high-affinity DNA aptamers using a library-immobilization based SELEX strategy. The lead aptamer, TOB-2, binds tobramycin with a dissociation constant of 420 nM as determined by isothermal titration calorimetry, while exhibiting...

#2 [14.8] A Targeted Nanozyme for STING Activation Improves BiTEs Therapy Outcomes in Colorectal Cancer.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with limited efficacy of conventional therapies due to immunosuppressive tumor microenvironments and high recurrence. While bispecific T-cell engagers (BiTEs) show promise by engaging T cells against tumors, their clinical translation is hindered by poor stabi...

#3 [13.6] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies.

Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins, and efficiently optimizing their binding affinities, remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experimental vali...

#4 [13.6] Therapeutic platforms for cancer management centered on blocking the PD-L1/PD-1 interaction through the use of aptamers: A review.

Blocking the PD-1/PD-L1 (Programmed Cell Death Protein-1/Programmed Cell Death Ligand-1) pathway represents a pivotal approach in cancer immunotherapy, effectively promoting sustained antitumor immune responses while alleviating immunosuppressive mechanisms. Advancing novel technologies to enhance the efficacy of PD-1/PD-L1 blockade remains a cr...

#5 [13.6] COF@DNAzyme Empowering Endogenous Copper for One‐Stitch Bioorthogonal Catalysis‐Based Anticancer Therapy

ABSTRACT Bioorthogonal chemistry, particularly the copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) reaction, holds great promise for in situ prodrug activation to minimize systemic toxicity in disease treatments. However, existing approaches mainly rely on exogenous copper catalysts, which pose a risk of disrupting copper homeostasis and suf...

#6 [13.6] COF@DNAzyme Empowering Endogenous Copper for One-Stitch Bioorthogonal Catalysis-Based Anticancer Therapy.

Bioorthogonal chemistry, particularly the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, holds great promise for in situ prodrug activation to minimize systemic toxicity in disease treatments. However, existing approaches mainly rely on exogenous copper catalysts, which pose a risk of disrupting copper homeostasis and suffer from ...

#7 [13.5] Non-Invasive Transdermal Delivery of miR-30a-5p via MUC1-Aptamer-Guided Tetrahedral DNA Nanostructures for Gene Silencing in Cutaneous Melanoma.

Cutaneous malignant melanoma is a highly aggressive skin cancer with poor prognosis. Although microRNA (miRNA)-based gene therapy shows promise, its clinical translation is limited by rapid degradation in serum and the barrier function of the stratum corneum. Herein, we engineer a programmable, targeted, and non-invasive nanoplatform, termed MAR...

#8 [12.8] Ultrasensitive electrochemiluminescence aptasensor for Tau protein based on gold nanoparticle-modified perovskite nanocrystals.

Early diagnosis for Alzheimer's disease (AD) is vital for effective therapeutic intervention and improved patient prognosis. In this work, we developed a highly sensitive electrochemiluminescence (ECL) aptasensor for detecting a key AD biomarker, Tau protein. An all-inorganic perovskite CsPbBr3 nanocrystals (NCs) were used as ECL emitters and we...

#9 [12.7] Membrane-anchored DNA nanodevice with allosteric aptamer arms enables parallel probing and on-site drug delivery.

DNA-based molecular computation enables targeting of cells via multiple surface receptors. However, existing platforms are often limited to single-receptor detection per operation or rely on freely diffusing components, a common source of off-target interference. Here we show an intelligent DNA nanodevice (DND) that integrates multivalent recogn...

#10 [12.6] A DNA aptamer targeting RANKL and its nanoparticle-mediated delivery ameliorate osteoporotic bone loss.

Osteoporosis management remains challenging, partly due to the poor bioavailability of drugs in bone and the systemic side effects of current treatments. To address this, we engineered a targeted nanomedicine therapy using a DNA aptamer that specifically binds RANKL, a pivotal regulator of bone resorption. The aptamer is conjugated to PEGylated ...

Methodology