Aptamer 学术简报 — therapeutic — 2026-07-08

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 83 篇命中（aptamer 池 229 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.1] High affinity and selective DNA aptamers for the detection of tobramycin in eye drops.

Tobramycin is a frontline aminoglycoside antibiotic with a narrow therapeutic window. Here, we report the selection of high-affinity DNA aptamers using a library-immobilization based SELEX strategy. The lead aptamer, TOB-2, binds tobramycin with a dissociation constant of 420 nM as determined by isothermal titration calorimetry, while exhibiting...

#2 [15.1] Ultrasensitive, Real-Time Molecular Sensing in Unprocessed Whole Blood Using Surface-Enhanced Raman Scattering Combined with Glycocalyx-Mimicking Structures.

Rapid, real-time, and ultrasensitive molecular sensing in unprocessed whole blood remains a major challenge due to biofouling, narrow dynamic ranges, and the need for rapid equilibration. We report a biomimetic surface-enhanced Raman scattering (SERS) platform that integrates structure-switching aptamers with a self-assembling, lubricin (proteog...

#3 [14.5] A Droplet-Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients' Blood Plasma Samples.

Breast cancer is highly heterogeneous, with distinct subtypes-luminal A, HER2-positive, and triple-negative-each exhibiting unique behaviors and treatment responses. Accurate identification of these subtypes is essential for guiding personalized therapies and improving outcomes. Exosomes, small extracellular vesicles secreted by tumor cells, hav...

#4 [14.0] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#5 [14.0] G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.

INTRODUCTION: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy. AREAS COVERED: This review summarizes structural and biolog...

#6 [13.9] High-Speed Atomic Force Microscopy Reveals Aptamer-Mediated Conformational Trapping of METTL3-METTL14 for m(6)A Inhibition.

The conformational dynamics of METTL3-METTL14 (M3/M14) heterodimer, the catalytic core for N6-methyladenosine (m6A) deposition, remain largely unexplored, limiting insight into dynamic regulation of catalysis and opportunities for therapeutic targeting in cancer. Here, we report the first single-molecule visualization of M3/M14 dynamics by high-...

#7 [13.6] Integrating DNA tetrahedron with affinity magnetic levitation for selective capture and sensitive detection of circulating tumor cells.

Circulating tumor cell (CTC) is an evidenced biomarker for early cancer diagnosis and assessment of treatment response. This necessitates increasing attempt to develop new method for detection of CTCs with highly enriching and anti-interference capacity. Herein, we built a simple platform for CTC detection by combining aptamer-mediated specific ...

#8 [13.6] Simulated construction of tilmicosin nucleic acid aptamers based on molecular docking and molecular dynamics techniques.

BACKGROUND: Traditional aptamer screening methods often prove ineffective for small molecule targets, primarily due to the inherent structural limitations of such compounds. Their simple architecture, limited functional groups, and restricted spatial complexity drastically reduce the probability of identifying nucleic acid sequences that bind wi...

#9 [13.6] An aptamer-mediated EXPAR fluorescence biosensor for early and sensitive detection of Aβ42 and Aβ40.

BACKGROUND: Alzheimer's disease (AD) is a common neurodegenerative disorder with increasing cases worldwide. Early screening is important for AD prevention and treatment, but current methods still face many challenges. RESULTS: To address these challenges, we developed a simple and novel molecular beacon (MB) fluorescent biosensor. This sensor c...

#10 [13.5] Porous Hydrogel-Mediated One-Step Selection of Mannoprotein-Targeted Aptamers for Early Diagnosis of Invasive Saccharomyces cerevisiae Infections.

Invasive fungal infections, particularly those caused by Saccharomyces cerevisiae, have emerged as a significant public health threat. Accurate and timely recognition of S. cerevisiae is essential for effective diagnosis and treatment. This study introduces a micro- and nanoscale-enabled diagnostic strategy that integrates porous hydrogel-mediat...

Methodology