Aptamer 学术简报 — therapeutic — 2026-07-05

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 78 篇命中（aptamer 池 233 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [24.0] High affinity and selective DNA aptamers for the detection of tobramycin in eye drops.

Tobramycin is a frontline aminoglycoside antibiotic with a narrow therapeutic window. Here, we report the selection of high-affinity DNA aptamers using a library-immobilization based SELEX strategy. The lead aptamer, TOB-2, binds tobramycin with a dissociation constant of 420 nM as determined by isothermal titration calorimetry, while exhibiting...

#2 [16.9] Ultrasensitive, Real-Time Molecular Sensing in Unprocessed Whole Blood Using Surface-Enhanced Raman Scattering Combined with Glycocalyx-Mimicking Structures.

Rapid, real-time, and ultrasensitive molecular sensing in unprocessed whole blood remains a major challenge due to biofouling, narrow dynamic ranges, and the need for rapid equilibration. We report a biomimetic surface-enhanced Raman scattering (SERS) platform that integrates structure-switching aptamers with a self-assembling, lubricin (proteog...

#3 [16.8] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#4 [16.8] G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.

INTRODUCTION: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy. AREAS COVERED: This review summarizes structural and biolog...

#5 [14.5] Porous Hydrogel-Mediated One-Step Selection of Mannoprotein-Targeted Aptamers for Early Diagnosis of Invasive Saccharomyces cerevisiae Infections.

Invasive fungal infections, particularly those caused by Saccharomyces cerevisiae, have emerged as a significant public health threat. Accurate and timely recognition of S. cerevisiae is essential for effective diagnosis and treatment. This study introduces a micro- and nanoscale-enabled diagnostic strategy that integrates porous hydrogel-mediat...

#6 [14.0] A bivalent anti-CTGF aptamer modulates multiple signaling pathways to attenuate liver fibrosis.

Liver fibrosis is a pressing clinical problem without effective drugs. Connective tissue growth factor (CTGF), as a pivotal driver of fibrosis, is targeted with a dimer-inducing strategy to inhibit its pro-fibrotic activity. Here, a series of high-affinity aptamers targeting CTGF are screened through micro-SELEX, among which CApt10 shows high ef...

#7 [13.9] Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Extracellular vesicles (EVs) have emerged as promising biomarkers for monitoring physiological homeostasis and pathological progression. However, current analytic methods face limitations in preserving spatial information about EVs and their intricate connections to parental and recipient cells. Here, we present Spatial-EV-seq, a method for in s...

#8 [13.8] DNA tetrahedron-mediated vascular targeted delivery of astragaloside IV enhances distraction osteogenesis via PI3K/AKT/FOXO pathway.

Bone regeneration during distraction osteogenesis (DO) remains limited by insufficient vascularization, which delays consolidation and compromises clinical outcomes. Here, we developed a vascular-targeted DNA nanoplatform (TDN@Ast-AptCD34) for the delivery of Astragaloside IV (Ast), a natural compound with pro-angiogenic and osteogenic propertie...

#9 [13.7] Double-Strand Gated Biosensor for Ultrasensitive T4 PNK Detection via λ-Exonuclease-Driven Background Suppression and Dimer G-Triplex Signal Amplification

Accurate monitoring of polynucleotide kinase (PNK) activity is essential for DNA repair studies and early clinical diagnostics. Conventional λ-exonuclease (λ-exo)-based biosensors often suffer from high background signals and false‑positive results, mainly due to nonspecific hydrolysis and unintended phosphorylation. To address these issues, we ...

#10 [13.6] Aptamer-Functionalized DNA Tetrahedra Loading GOx/HRP Cascade System for Targeted Therapy of Infected Wounds.

The skin serves as the primary barrier for human health, yet its integrity is frequently compromised by environmental stressors, leading to wounds where bacterial infection poses a significant clinical obstacle. To address escalating antibiotic resistance and the biocompatibility issues of exogenous antibacterial agents, this project developed a...

Methodology