Aptamer 学术简报 — therapeutic — 2026-07-04

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 73 篇命中（aptamer 池 215 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [25.4] High affinity and selective DNA aptamers for the detection of tobramycin in eye drops.

Tobramycin is a frontline aminoglycoside antibiotic with a narrow therapeutic window. Here, we report the selection of high-affinity DNA aptamers using a library-immobilization based SELEX strategy. The lead aptamer, TOB-2, binds tobramycin with a dissociation constant of 420 nM as determined by isothermal titration calorimetry, while exhibiting...

#2 [18.1] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#3 [18.1] G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.

INTRODUCTION: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy. AREAS COVERED: This review summarizes structural and biolog...

#4 [17.6] Ultrasensitive, Real-Time Molecular Sensing in Unprocessed Whole Blood Using Surface-Enhanced Raman Scattering Combined with Glycocalyx-Mimicking Structures.

Rapid, real-time, and ultrasensitive molecular sensing in unprocessed whole blood remains a major challenge due to biofouling, narrow dynamic ranges, and the need for rapid equilibration. We report a biomimetic surface-enhanced Raman scattering (SERS) platform that integrates structure-switching aptamers with a self-assembling, lubricin (proteog...

#5 [14.8] Porous Hydrogel-Mediated One-Step Selection of Mannoprotein-Targeted Aptamers for Early Diagnosis of Invasive Saccharomyces cerevisiae Infections.

Invasive fungal infections, particularly those caused by Saccharomyces cerevisiae, have emerged as a significant public health threat. Accurate and timely recognition of S. cerevisiae is essential for effective diagnosis and treatment. This study introduces a micro- and nanoscale-enabled diagnostic strategy that integrates porous hydrogel-mediat...

#6 [14.2] Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Extracellular vesicles (EVs) have emerged as promising biomarkers for monitoring physiological homeostasis and pathological progression. However, current analytic methods face limitations in preserving spatial information about EVs and their intricate connections to parental and recipient cells. Here, we present Spatial-EV-seq, a method for in s...

#7 [14.1] DNA tetrahedron-mediated vascular targeted delivery of astragaloside IV enhances distraction osteogenesis via PI3K/AKT/FOXO pathway.

Bone regeneration during distraction osteogenesis (DO) remains limited by insufficient vascularization, which delays consolidation and compromises clinical outcomes. Here, we developed a vascular-targeted DNA nanoplatform (TDN@Ast-AptCD34) for the delivery of Astragaloside IV (Ast), a natural compound with pro-angiogenic and osteogenic propertie...

#8 [14.0] Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells.

Abnormal decidual natural killer cell (dNK) function is linked to pregnancy complications occurring in both early and late gestation, including recurrent pregnancy loss, preeclampsia, and preterm birth. Exploration of dNK heterogeneity as it relates to function is an active area of research; however, most of this work has focused on early gestat...

#9 [13.9] Aptamer-Functionalized DNA Tetrahedra Loading GOx/HRP Cascade System for Targeted Therapy of Infected Wounds.

The skin serves as the primary barrier for human health, yet its integrity is frequently compromised by environmental stressors, leading to wounds where bacterial infection poses a significant clinical obstacle. To address escalating antibiotic resistance and the biocompatibility issues of exogenous antibacterial agents, this project developed a...

#10 [13.1] Aptamer-functionalized tetrahedral framework nucleic acid delivery of siBhlhe22 for repairing osteoporotic bone defects via dual modulation of PI3K-Akt signaling and purine metabolism.

Osteoporosis is characterized by an imbalance between bone formation and resorption, and the dysregulated differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a central role. Our previous study identified Bhlhe22 as a key negative regulator of osteogenic differentiation; here, we further validate its role in osteoporotic BMSCs (OP...

Methodology