Aptamer 学术简报 — therapeutic — 2026-06-25

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 60 篇命中（aptamer 池 182 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.3] Late-Stage Carboranylation of Nucleos(t)ides Enabled by Minisci and Pd-Catalyzed B-N Cross-Coupling Reactions: Toward the Synthesis of Carboranyl-Modified Oligonucleotides.

Carboranyl-modified nucleosides are promising boron-10 (10B) delivery agents for boron neutron capture therapy (BNCT), yet methods for directly forming B-C/B-N bonds at unprotected nucleosides are scarce. We report herein two operationally simple, orthogonal strategies for the late-stage installation of carboranyl units at heteroaromatic C(sp2) ...

#2 [14.3] Aptamer-Functionalized Liposome Delivery System Based on Multifunctional Microreactor Design.

Breast cancer remains the leading cause of cancer-related mortality in women, with conventional chemotherapy often limited by systemic toxicity due to poor drug targeting. Here, we present an integrated microfluidic chip (MMLP) that enables one-step integrated postprocessing, including solvent removal and ligand conjugation. The MMLP chip combin...

#3 [13.9] Aptamer-tagged exosome-coated Bismuth ferrite-mesoporous silica nanoparticle for chemoradiotherapy and CT/MR imaging of non-small cell lung cancer.

The combination of chemotherapy and radiation therapy (RT) can significantly enhance anticancer efficacy, and nanoparticle-based systems that function as both radiosensitizers and drug carriers offer a promising strategy for multimodal cancer treatment. Here, we developed a core-shell nanoplatform composed of a bismuth ferrite (BiFeO3, BFO) core...

#4 [13.7] Aptagel Plasmonic Fiber Optic Biosensor for In Vivo Continuous Drug Monitoring.

Continuous monitoring of drug dynamics directly in living tissue remains a major challenge, notably in the brain, where the blood-brain barrier creates distinct microenvironments. Here, we report an implantable fiber optic surface plasmon resonance (FO-SPR) biosensor coated with aptagel, a split-aptamer-crosslinked hydrogel, for continuous monit...

#5 [12.8] Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis.

Recently, targeted protein degradation (TPD) strategies have emerged as an effective tool for addressing undruggable targets in both biomedical research and the pharmaceutical industry, selectively binding proteins of interest and targeting them to the intracellular degradation machinery for degradation. However, the targeting of extracellular p...

#6 [12.0] A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Targeting post-transcriptional dysregulation of tumor suppressors represents a new frontier in cancer therapy. Here, we identify the alternative polyadenylation (APA) regulator NUDT21 as a pivotal therapeutic target in oral squamous cell carcinoma (OSCC). NUDT21 is highly upregulated, correlating strongly with poor survival and advanced clinical...

#7 [12.0] Real-Time Monitoring of Trastuzumab Monoclonal Antibodies Using Electrochemical Aptamer-Based Sensors.

The real-time monitoring of trastuzumab (Tmab), a monoclonal antibody used for cancer treatment, is critical for personalized, response-guided dosing and improved biomanufacturing quality control. Currently, Tmab concentrations are quantified using immunoassays and mass spectrometry, but these platforms provide only discrete measurements and req...

#8 [11.9] A combined ultrasound-enzymolysis-peptide aptamers strategy for reducing whey protein concentrate allergenicity in infant formula.

This study developed a combined ultrasound-enzymolysis-peptide aptamers method to reduce residual antigenicity of whey protein concentrate (WPC) in infant formula. The results indicated that 150 W ultrasonic treatment significantly altered the structure of WPC, increasing the β-sheet content by 14.55%, maximizing the exposure of total and surfac...

#9 [11.1] Engineering human PEG10-based nanoparticles for RNA self-packaging, delivery and cancer therapy

PEG10 protein was recently uncovered to self-assemble and self-package its own mRNA into nanoparticles, but the particles require expensive transfection for production and have yet to be explored for cancer therapy. Here we develop a human PEG10-based nanoparticles (PBNPs) platform for cargo RNA self-packaging and delivery for cancer therapy. We...

#10 [10.3] Multifunctional DNA Nanoplatform Based on CuInS/ZnS QDs and Rolling Circle Amplification for Synergistic PTT/CDT/CT of Multidrug Resistant Cancer Cells.

Synergistic therapy holds significant potential in cancer diagnosis and treatment, yet faces substantial challenges such as nonspecific drug release and tumor multidrug resistance (MDR). Herein, we report a self-assembled DNA nanoplatform (ZCIS QDs@RD) based on CuInS/ZnS QDs (ZCIS QDs) and rolling circle amplification (RCA) for synergistic photo...

Methodology