Aptamer 学术简报 — therapeutic — 2026-06-21

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 63 篇命中（aptamer 池 166 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.2] Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis.

Recently, targeted protein degradation (TPD) strategies have emerged as an effective tool for addressing undruggable targets in both biomedical research and the pharmaceutical industry, selectively binding proteins of interest and targeting them to the intracellular degradation machinery for degradation. However, the targeting of extracellular p...

#2 [13.3] Real-Time Monitoring of Trastuzumab Monoclonal Antibodies Using Electrochemical Aptamer-Based Sensors.

The real-time monitoring of trastuzumab (Tmab), a monoclonal antibody used for cancer treatment, is critical for personalized, response-guided dosing and improved biomanufacturing quality control. Currently, Tmab concentrations are quantified using immunoassays and mass spectrometry, but these platforms provide only discrete measurements and req...

#3 [13.3] A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Targeting post-transcriptional dysregulation of tumor suppressors represents a new frontier in cancer therapy. Here, we identify the alternative polyadenylation (APA) regulator NUDT21 as a pivotal therapeutic target in oral squamous cell carcinoma (OSCC). NUDT21 is highly upregulated, correlating strongly with poor survival and advanced clinical...

#4 [13.2] A combined ultrasound-enzymolysis-peptide aptamers strategy for reducing whey protein concentrate allergenicity in infant formula.

This study developed a combined ultrasound-enzymolysis-peptide aptamers method to reduce residual antigenicity of whey protein concentrate (WPC) in infant formula. The results indicated that 150 W ultrasonic treatment significantly altered the structure of WPC, increasing the β-sheet content by 14.55%, maximizing the exposure of total and surfac...

#5 [12.4] Engineering human PEG10-based nanoparticles for RNA self-packaging, delivery and cancer therapy

PEG10 protein was recently uncovered to self-assemble and self-package its own mRNA into nanoparticles, but the particles require expensive transfection for production and have yet to be explored for cancer therapy. Here we develop a human PEG10-based nanoparticles (PBNPs) platform for cargo RNA self-packaging and delivery for cancer therapy. We...

#6 [11.9] Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design.

Nucleic acid aptamers are synthetic, single-stranded oligonucleotides that bind targets with high affinity and specificity, enabling precise and programmable functional modulation. However, low biostability remains a key druggability bottleneck of therapeutic aptamers. In vivo enzymatic lability constitutes a primary pharmacokinetic barrier, imp...

#7 [11.6] Multifunctional DNA Nanoplatform Based on CuInS/ZnS QDs and Rolling Circle Amplification for Synergistic PTT/CDT/CT of Multidrug Resistant Cancer Cells.

Synergistic therapy holds significant potential in cancer diagnosis and treatment, yet faces substantial challenges such as nonspecific drug release and tumor multidrug resistance (MDR). Herein, we report a self-assembled DNA nanoplatform (ZCIS QDs@RD) based on CuInS/ZnS QDs (ZCIS QDs) and rolling circle amplification (RCA) for synergistic photo...

#8 [11.5] Aptamers: Current Applications in Leukemia Diagnostics and Therapeutics.

Aptamers are single-stranded synthetic oligonucleotides that bind noncovalently to targets with high affinity and selectivity. They are generated through an in vitro selection process known as Systematic Evolution of Ligands by Exponential Enrichment. Aptamers show significant promise in cancer diagnostics and therapeutics due to their specifici...

#9 [11.3] A Photosensitizer-Intercalated Programmable DNA System for Enhanced Photoimmunotherapy via Tumor Microenvironment Remodeling.

Photoimmunotherapy (PIT) has emerged as a minimally invasive therapeutic modality for cancer, offering high spatial precision and favorable therapeutic outcomes. However, the aggregation-caused quenching (ACQ) of photosensitizers and the hypoxic tumor microenvironment (TME) limit its overall efficacy. Herein, a DNA tetrahedron-based nanoplatform...

#10 [11.3] Protein Binding and Molecular Size Govern Molecular Transport into Dermal Interstitial Fluid.

Dermal interstitial fluid (ISF) has emerged as the leading frontier for real-time molecular monitoring due to its rapid equilibration with blood and its role in carrying biomarkers that may reflect health status. To access ISF, we and others have developed microneedle sensor arrays, composed of microscopic probes that penetrate the epidermis pai...

Methodology