Aptamer 学术简报 — therapeutic — 2026-06-14

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 79 篇命中（aptamer 池 228 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.1] Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design.

Nucleic acid aptamers are synthetic, single-stranded oligonucleotides that bind targets with high affinity and specificity, enabling precise and programmable functional modulation. However, low biostability remains a key druggability bottleneck of therapeutic aptamers. In vivo enzymatic lability constitutes a primary pharmacokinetic barrier, imp...

#2 [14.7] Engineering human PEG10-based nanoparticles for RNA self-packaging, delivery and cancer therapy

PEG10 protein was recently uncovered to self-assemble and self-package its own mRNA into nanoparticles, but the particles require expensive transfection for production and have yet to be explored for cancer therapy. Here we develop a human PEG10-based nanoparticles (PBNPs) platform for cargo RNA self-packaging and delivery for cancer therapy. We...

#3 [13.9] Multifunctional DNA Nanoplatform Based on CuInS/ZnS QDs and Rolling Circle Amplification for Synergistic PTT/CDT/CT of Multidrug Resistant Cancer Cells.

Synergistic therapy holds significant potential in cancer diagnosis and treatment, yet faces substantial challenges such as nonspecific drug release and tumor multidrug resistance (MDR). Herein, we report a self-assembled DNA nanoplatform (ZCIS QDs@RD) based on CuInS/ZnS QDs (ZCIS QDs) and rolling circle amplification (RCA) for synergistic photo...

#4 [13.7] A Photosensitizer-Intercalated Programmable DNA System for Enhanced Photoimmunotherapy via Tumor Microenvironment Remodeling.

Photoimmunotherapy (PIT) has emerged as a minimally invasive therapeutic modality for cancer, offering high spatial precision and favorable therapeutic outcomes. However, the aggregation-caused quenching (ACQ) of photosensitizers and the hypoxic tumor microenvironment (TME) limit its overall efficacy. Herein, a DNA tetrahedron-based nanoplatform...

#5 [13.7] Protein Binding and Molecular Size Govern Molecular Transport into Dermal Interstitial Fluid.

Dermal interstitial fluid (ISF) has emerged as the leading frontier for real-time molecular monitoring due to its rapid equilibration with blood and its role in carrying biomarkers that may reflect health status. To access ISF, we and others have developed microneedle sensor arrays, composed of microscopic probes that penetrate the epidermis pai...

#6 [13.6] Enhancing small-molecule-mediated translational control through multivalent RNA aptamers.

The precise translational control of gene expression by small molecules through RNA-based switches holds considerable promise for both research and therapeutic developments. However, current high-performance RNA switches remain limited in adaptability, with strong responses typically constrained to a narrow set of specific ligand-aptamer pairs. ...

#7 [13.6] Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy.

Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell activation. Here we develop a DNA-logic CAR (DL-CAR) system that enables programmable targeting and precise ablation of tumors with specific antigen combination patterns. The ...

#8 [13.5] Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.

Cardiovascular diseases (CVDs) are globally prevalent pathologies driven by dysregulated signaling networks. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs produced by back-splicingmechanism, in which a downstream 5' splice site joins an upstream 3' splice site, have emerged as critical regulators of CVD pathogenesis. Thi...

#9 [13.5] DNA hydrogel-delivered hypoxic exosomes alleviate radiation-induced skin injury by stabilizing AKT.

BACKGROUND: Radiation-induced skin injury (RISI) is a common and refractory complication during tumor radiotherapy, characterized by radiation stress-induced impairment of keratinocyte viability and regenerative signaling, ultimately leading to delayed skin repair. Recently, hypoxia-preconditioned adipose-derived stem cell-derived exosomes (A-He...

#10 [13.2] Protamine-modified CuAu nanocarrier enhances aptamer-mediated synergistic therapy for breast cancer.

Although aptamers held promise for precision cancer therapy, their physiological instability and the lack of multifunctional delivery platforms that enabled synergistic therapeutic effects remained key challenges. In this study, a nanocarrier based on protamine-modified CuAu bimetallic nanozyme was constructed to co-load AT11 aptamer and Doxorub...

Methodology