Aptamer 学术简报 — therapeutic — 2026-06-12

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 65 篇命中（aptamer 池 218 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.8] Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.

Cardiovascular diseases (CVDs) are globally prevalent pathologies driven by dysregulated signaling networks. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs produced by back-splicingmechanism, in which a downstream 5' splice site joins an upstream 3' splice site, have emerged as critical regulators of CVD pathogenesis. Thi...

#2 [14.3] Enhancing small-molecule-mediated translational control through multivalent RNA aptamers.

The precise translational control of gene expression by small molecules through RNA-based switches holds considerable promise for both research and therapeutic developments. However, current high-performance RNA switches remain limited in adaptability, with strong responses typically constrained to a narrow set of specific ligand-aptamer pairs. ...

#3 [14.2] Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy.

Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell activation. Here we develop a DNA-logic CAR (DL-CAR) system that enables programmable targeting and precise ablation of tumors with specific antigen combination patterns. The ...

#4 [14.1] DNA hydrogel-delivered hypoxic exosomes alleviate radiation-induced skin injury by stabilizing AKT.

BACKGROUND: Radiation-induced skin injury (RISI) is a common and refractory complication during tumor radiotherapy, characterized by radiation stress-induced impairment of keratinocyte viability and regenerative signaling, ultimately leading to delayed skin repair. Recently, hypoxia-preconditioned adipose-derived stem cell-derived exosomes (A-He...

#5 [13.9] Protamine-modified CuAu nanocarrier enhances aptamer-mediated synergistic therapy for breast cancer.

Although aptamers held promise for precision cancer therapy, their physiological instability and the lack of multifunctional delivery platforms that enabled synergistic therapeutic effects remained key challenges. In this study, a nanocarrier based on protamine-modified CuAu bimetallic nanozyme was constructed to co-load AT11 aptamer and Doxorub...

#6 [13.7] Functionalized Fluorescent Nanodiamonds Reveal Therapeutic Protein Clearance Through ENDOTAC Linked to AUTOTAC

Targeted protein degradation has emerged as a transformative therapeutic modality in cancer therapy, enabling the elimination of undruggable proteins and overcoming conventional small-molecule resistance. Therapeutic approaches such as endocytosis-targeting chimera (ENDOTAC) and autophagy-targeting chimera (AUTOTAC) facilitate undruggable protei...

#7 [13.5] Multivalent Aptamers: Contemporary Engineering Strategies and Biomedical Applications.

Nucleic acid aptamers represent a distinctive class of molecular recognition elements with high binding affinity, excellent chemical stability, and low immunogenicity, making them powerful tools for diverse biomedical applications. Nevertheless, monovalent aptamers are often constrained by limited binding avidity, suboptimal pharmacokinetics, an...

#8 [13.4] Aptamer-guided upconversion nanoconstructs enable proximity-dependent and precise photodynamic therapy for MRSA-infected wounds.

Methicillin-resistant Staphylococcus aureus (MRSA) infections lead to slow wound healing, but treating these wounds with conventional photodynamic therapy (PDT) remains challenging because they induce non-specific oxidative damage on healthy tissue, thereby hindering wound repair. To achieve efficient antibacterial activity while avoiding non-sp...

#9 [12.5] Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

Longitudinal monitoring of tumor progression and metastasis provides significant benefits to improve the treatment outcome of breast cancer. Matrix metalloproteinase 14 (MMP14) on extracellular vesicles (EVs) is highly relevant to tumor invasiveness, yet the sensitivity and specificity of detection are hindered by tremendous amounts of normal EV...

#10 [12.5] Electrochemically activated DNA circuit for the amplified and accurate biosensing of cancer cells.

The detection of cancer cells not only facilitates the early diagnosis of cancers but also provides valuable support for formulating personalized treatment plans for patients. In this work, we develop a new aptamer-based electrochemical biosensing method for cancer cell detection, employing an electrochemically activated DNA circuit as a signal ...

Methodology