Aptamer 学术简报 — therapeutic — 2026-06-10

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 69 篇命中（aptamer 池 229 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.1] Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.

Cardiovascular diseases (CVDs) are globally prevalent pathologies driven by dysregulated signaling networks. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs produced by back-splicingmechanism, in which a downstream 5' splice site joins an upstream 3' splice site, have emerged as critical regulators of CVD pathogenesis. Thi...

#2 [14.9] Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy.

Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell activation. Here we develop a DNA-logic CAR (DL-CAR) system that enables programmable targeting and precise ablation of tumors with specific antigen combination patterns. The ...

#3 [14.7] Aptamer-guided upconversion nanoconstructs enable proximity-dependent and precise photodynamic therapy for MRSA-infected wounds.

Methicillin-resistant Staphylococcus aureus (MRSA) infections lead to slow wound healing, but treating these wounds with conventional photodynamic therapy (PDT) remains challenging because they induce non-specific oxidative damage on healthy tissue, thereby hindering wound repair. To achieve efficient antibacterial activity while avoiding non-sp...

#4 [14.2] Multivalent Aptamers: Contemporary Engineering Strategies and Biomedical Applications.

Nucleic acid aptamers represent a distinctive class of molecular recognition elements with high binding affinity, excellent chemical stability, and low immunogenicity, making them powerful tools for diverse biomedical applications. Nevertheless, monovalent aptamers are often constrained by limited binding avidity, suboptimal pharmacokinetics, an...

#5 [13.2] Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

Longitudinal monitoring of tumor progression and metastasis provides significant benefits to improve the treatment outcome of breast cancer. Matrix metalloproteinase 14 (MMP14) on extracellular vesicles (EVs) is highly relevant to tumor invasiveness, yet the sensitivity and specificity of detection are hindered by tremendous amounts of normal EV...

#6 [13.1] Electrochemically activated DNA circuit for the amplified and accurate biosensing of cancer cells.

The detection of cancer cells not only facilitates the early diagnosis of cancers but also provides valuable support for formulating personalized treatment plans for patients. In this work, we develop a new aptamer-based electrochemical biosensing method for cancer cell detection, employing an electrochemically activated DNA circuit as a signal ...

#7 [12.9] Unlocking chemical diversity in aptamers with DNA orthogonal barcodes.

Aptamers are a versatile alternative to antibodies as they are smaller, easier to synthesize and less immunogenic. However, while antibodies are composed of 20 chemically diverse amino acids and are established therapeutics, aptamers are composed of only 4 similar nucleobases, thereby limiting their therapeutic potential. Aptamer chemical modifi...

#8 [12.7] A Proximity-Induced pH-Responsive DNA Switch for Reversible Capture and Release of Extracellular Vesicles.

Extracellular vesicles (EV) serve as critical mediators in physiological and pathological processes, holding great promise for cancer diagnosis, real-time monitoring, and prognostic applications. However, their small size and low density present considerable challenges in achieving efficient, specific, and mild isolation, which currently hinders...

#9 [12.6] Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.

BACKGROUND: Joint use of multiple molecular layers can be useful to prioritize targets for mechanistic studies. Application of this approach to coronary disease in large populations is an emerging field. METHODS: We used reported circulating proteomic data (Somascan aptamer-based) from ≈3000 individuals in the CARDIA study (Coronary Artery Risk ...

#10 [12.5] A label-free electrochemical aptasensor enables ultrasensitive and specific detection of neurofilament light.

Plasma neurofilament light chain (NfL) has been identified as a promising early-stage Alzheimer's disease (AD) biomarker, reflecting neuroaxonal degeneration at preclinical stages. However, its extremely low concentration in blood presents a major analytical challenge. Although single-molecule array (Simoa) assays provide exceptional sensitivity...

Methodology