Aptamer 学术简报 — therapeutic — 2026-06-05

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 68 篇命中（aptamer 池 234 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [20.7] Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.

Cardiovascular diseases (CVDs) are globally prevalent pathologies driven by dysregulated signaling networks. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs produced by back-splicingmechanism, in which a downstream 5' splice site joins an upstream 3' splice site, have emerged as critical regulators of CVD pathogenesis. Thi...

#2 [16.8] Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.

BACKGROUND: Joint use of multiple molecular layers can be useful to prioritize targets for mechanistic studies. Application of this approach to coronary disease in large populations is an emerging field. METHODS: We used reported circulating proteomic data (Somascan aptamer-based) from ≈3000 individuals in the CARDIA study (Coronary Artery Risk ...

#3 [14.8] Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

Longitudinal monitoring of tumor progression and metastasis provides significant benefits to improve the treatment outcome of breast cancer. Matrix metalloproteinase 14 (MMP14) on extracellular vesicles (EVs) is highly relevant to tumor invasiveness, yet the sensitivity and specificity of detection are hindered by tremendous amounts of normal EV...

#4 [14.5] Unlocking chemical diversity in aptamers with DNA orthogonal barcodes.

Aptamers are a versatile alternative to antibodies as they are smaller, easier to synthesize and less immunogenic. However, while antibodies are composed of 20 chemically diverse amino acids and are established therapeutics, aptamers are composed of only 4 similar nucleobases, thereby limiting their therapeutic potential. Aptamer chemical modifi...

#5 [13.8] Dynamic Switchable and Transient DNA Condensates Driven by Aptamer-Ligand or Ion-Nucleobase Bridged Complexes.

Phase-separated DNA-based coacervates undergoing dynamic switchable or transient evolution and depletion are introduced. Y-shaped DNA reaction modules crosslinked by palindromic strands conjugated to cooperatively stabilized metal-ions/mismatched bridges, C-Ag+-C or T-Hg2+-T, evolved phase-separated microdroplets. Removal of the bridging ions by...

#6 [13.5] Bispecific aptamer LYTAC for PCSK9 degradation: a promising strategy for cholesterol regulation.

PCSK9 is a key regulator of LDLR turnover and an established therapeutic target for CVD. Here, we report the development of a bispecific DNA aptamer-based lysosome-targeting chimera (PCSK9-LYTAC) that promotes extracellular degradation of PCSK9 via IGFIIR-mediated lysosomal trafficking. This dual-aptamer construct simultaneously blocks the PCSK9...

#7 [13.3] Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.

Oligonucleotide-based therapeutics offer precise genetic and immunological modulation but meet critical barriers including instability, poor cellular uptake, and carrier-associated toxicity. Although spherical nucleic acids (SNAs) provide a robust framework, the conventional designs relied on inactive cores impede multifunctional combinations an...

#8 [13.0] An Exosome RNA In Situ Detection Platform Based on a Regulated CRISPR/Cas12a Activity System and Its Application in Tumor Progression Monitoring and Therapeutic Efficacy Evaluation.

Tumor-derived exosomes, serving as promising biomarkers, hold substantial potential for reflecting the progression of diseases and assessing the efficacy of antitumor therapies. In this study, we developed a liposome-based platform capable of both precise recognition of tumor-derived exosomes and highly sensitive in situ analysis of the internal...

#9 [12.9] Structural characterization and molecular interaction studies of a novel RNA aptamer-MC1R macromolecular system using integrated computational and experimental approaches.

The structure-guided design of RNA aptamers targeting membrane proteins represents a growing opportunity, particularly given the therapeutic potential of nucleic acid therapeutics and the prevalence of G protein-coupled receptors (GPCRs) as drug targets. Here, we report an integrated computational and experimental approach to prioritize and stru...

#10 [12.9] Circular RNA in human brain: Systematic review of synaptic functions and disease associations.

Circular RNAs (circRNAs) are covalently closed, non-canonical transcripts, highly enriched in the mammalian brain and especially synaptic compartments. Generated via back-splicing of precursor mRNAs, their intrinsic stability and spatiotemporally regulated expression enable the modulating function for synaptic physiology through multiple mechani...

Methodology