Aptamer 学术简报 — therapeutic — 2026-06-04

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 65 篇命中（aptamer 池 221 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [22.1] Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.

Cardiovascular diseases (CVDs) are globally prevalent pathologies driven by dysregulated signaling networks. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs produced by back-splicingmechanism, in which a downstream 5' splice site joins an upstream 3' splice site, have emerged as critical regulators of CVD pathogenesis. Thi...

#2 [18.1] Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.

BACKGROUND: Joint use of multiple molecular layers can be useful to prioritize targets for mechanistic studies. Application of this approach to coronary disease in large populations is an emerging field. METHODS: We used reported circulating proteomic data (Somascan aptamer-based) from ≈3000 individuals in the CARDIA study (Coronary Artery Risk ...

#3 [15.2] Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

Longitudinal monitoring of tumor progression and metastasis provides significant benefits to improve the treatment outcome of breast cancer. Matrix metalloproteinase 14 (MMP14) on extracellular vesicles (EVs) is highly relevant to tumor invasiveness, yet the sensitivity and specificity of detection are hindered by tremendous amounts of normal EV...

#4 [14.2] Dynamic Switchable and Transient DNA Condensates Driven by Aptamer-Ligand or Ion-Nucleobase Bridged Complexes.

Phase-separated DNA-based coacervates undergoing dynamic switchable or transient evolution and depletion are introduced. Y-shaped DNA reaction modules crosslinked by palindromic strands conjugated to cooperatively stabilized metal-ions/mismatched bridges, C-Ag+-C or T-Hg2+-T, evolved phase-separated microdroplets. Removal of the bridging ions by...

#5 [13.7] Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.

Oligonucleotide-based therapeutics offer precise genetic and immunological modulation but meet critical barriers including instability, poor cellular uptake, and carrier-associated toxicity. Although spherical nucleic acids (SNAs) provide a robust framework, the conventional designs relied on inactive cores impede multifunctional combinations an...

#6 [13.3] An Exosome RNA In Situ Detection Platform Based on a Regulated CRISPR/Cas12a Activity System and Its Application in Tumor Progression Monitoring and Therapeutic Efficacy Evaluation.

Tumor-derived exosomes, serving as promising biomarkers, hold substantial potential for reflecting the progression of diseases and assessing the efficacy of antitumor therapies. In this study, we developed a liposome-based platform capable of both precise recognition of tumor-derived exosomes and highly sensitive in situ analysis of the internal...

#7 [13.2] Structural characterization and molecular interaction studies of a novel RNA aptamer-MC1R macromolecular system using integrated computational and experimental approaches.

The structure-guided design of RNA aptamers targeting membrane proteins represents a growing opportunity, particularly given the therapeutic potential of nucleic acid therapeutics and the prevalence of G protein-coupled receptors (GPCRs) as drug targets. Here, we report an integrated computational and experimental approach to prioritize and stru...

#8 [13.0] Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects.

Despite significant advances in precision oncology, key oncoproteins such as Ras, MYC, and p53 remain historically difficult to drug. Conventional pharmacologic strategies are fundamentally constrained by their dependency on direct interactions with well-defined structural domains, which these targets lack. Nucleic acid therapeutics offer a tran...

#9 [12.8] Ratiometric fluorescence aptasensor based on hollow mesoporous silica for gentamicin detection.

Gentamicin (GEN) is an aminoglycoside antibiotic widely used in animal husbandry because of its low cost and high therapeutic efficacy; however, its residues in milk pose a potential risk to food safety. In this study, a truncated aptamer (G41) with high affinity toward GEN was obtained through molecular docking and molecular dynamics simulation...

#10 [12.7] Profiling of extracellular vesicles from primary hepatocytes, organoids, and mash patients identifies cell injury-specific signatures.

Metabolic Dysfunction-Associated Steatohepatitis (MASH) is a severe form of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), traditionally diagnosed via invasive biopsy, underscoring the need for non-invasive alternatives. This study identifies biologically relevant extracellular vesicle (EV) protein signatures associated with M...

Methodology