Aptamer 学术简报 — therapeutic — 2026-06-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 62 篇命中（aptamer 池 248 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.7] Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.

Oligonucleotide-based therapeutics offer precise genetic and immunological modulation but meet critical barriers including instability, poor cellular uptake, and carrier-associated toxicity. Although spherical nucleic acids (SNAs) provide a robust framework, the conventional designs relied on inactive cores impede multifunctional combinations an...

#2 [14.2] Structural characterization and molecular interaction studies of a novel RNA aptamer-MC1R macromolecular system using integrated computational and experimental approaches.

The structure-guided design of RNA aptamers targeting membrane proteins represents a growing opportunity, particularly given the therapeutic potential of nucleic acid therapeutics and the prevalence of G protein-coupled receptors (GPCRs) as drug targets. Here, we report an integrated computational and experimental approach to prioritize and stru...

#3 [14.0] Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects.

Despite significant advances in precision oncology, key oncoproteins such as Ras, MYC, and p53 remain historically difficult to drug. Conventional pharmacologic strategies are fundamentally constrained by their dependency on direct interactions with well-defined structural domains, which these targets lack. Nucleic acid therapeutics offer a tran...

#4 [13.8] Ratiometric fluorescence aptasensor based on hollow mesoporous silica for gentamicin detection.

Gentamicin (GEN) is an aminoglycoside antibiotic widely used in animal husbandry because of its low cost and high therapeutic efficacy; however, its residues in milk pose a potential risk to food safety. In this study, a truncated aptamer (G41) with high affinity toward GEN was obtained through molecular docking and molecular dynamics simulation...

#5 [13.7] Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries.

Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable ...

#6 [13.7] Discriminating Post-Transplant Rejection from Infection by Detecting TCR-CD3 Oligomerization on Extracellular Vesicles Using a Ratiometric Caliper Probe.

Post-transplant rejection and infection remain significant obstacles to long-term patient survival. However, there is currently no standardized assay to simultaneously assess an individual patient's risk for both complications. Here, we demonstrate that T cell receptor (TCR)-CD3 oligomers on extracellular vesicles (EVs) represent a promising bio...

#7 [13.1] Screening molecular recognition element-based SWCNT optical sensors for the inflammatory cytokine TNF-α.

TNF-α (Tumor Necrosis Factor) is a proinflammatory cytokine that amplifies inflammatory response and promotes leukocyte recruitment. TNF-α is primarily produced by activated macrophages, among others, in response to infection, inflammation, or tissue damage. Given its central role in normal and abnormal immune responses, it is the target of seve...

#8 [12.7] Enzyme-Activated Molecular MRI for Specific Delineation of the Ischemic Penumbra in acute ischemic stroke.

Ischemic stroke, the second leading cause of death and a primary source of severe disability in adults worldwide, is associated with high morbidity and mortality rates that correlate closely with the extent of neuronal damage. A critical strategy for improving patient outcomes is the early identification and rescue of the ischemic penumbra, a re...

#9 [12.2] Auto-SELEX: a fully automated microfluidic platform for rapid discovery of high-affinity aptamers.

Aptamers are synthetic single-stranded oligonucleotides that fold into defined three-dimensional structures, enabling high-affinity and highly selective target recognition, and are increasingly explored as alternatives to antibodies in diagnostics and therapeutics owing to advantages in production cost, reproducibility, thermal stability, and ge...

#10 [11.7] Discovery and Cryo-EM-Guided Development of a Neuropilin-2-Binding Aptamer for Receptor Antagonism.

Receptor antagonists represent a major class of targeted cancer therapeutics, yet SELEX-based aptamer discovery often yields high-affinity binders that display limited functional blockade because epitope positioning is not explicitly selected. Herein, we report a multistage discovery and optimization workflow that integrates cell-SELEX, cryo-ele...

Methodology