Aptamer 学术简报 — therapeutic — 2026-05-31

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 48 篇命中（aptamer 池 212 篇）。

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#1 [14.3] Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects.

Despite significant advances in precision oncology, key oncoproteins such as Ras, MYC, and p53 remain historically difficult to drug. Conventional pharmacologic strategies are fundamentally constrained by their dependency on direct interactions with well-defined structural domains, which these targets lack. Nucleic acid therapeutics offer a tran...

#2 [14.1] Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries.

Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable ...

#3 [14.0] Discriminating Post-Transplant Rejection from Infection by Detecting TCR-CD3 Oligomerization on Extracellular Vesicles Using a Ratiometric Caliper Probe.

Post-transplant rejection and infection remain significant obstacles to long-term patient survival. However, there is currently no standardized assay to simultaneously assess an individual patient's risk for both complications. Here, we demonstrate that T cell receptor (TCR)-CD3 oligomers on extracellular vesicles (EVs) represent a promising bio...

#4 [13.0] Enzyme-Activated Molecular MRI for Specific Delineation of the Ischemic Penumbra in acute ischemic stroke.

Ischemic stroke, the second leading cause of death and a primary source of severe disability in adults worldwide, is associated with high morbidity and mortality rates that correlate closely with the extent of neuronal damage. A critical strategy for improving patient outcomes is the early identification and rescue of the ischemic penumbra, a re...

#5 [12.5] Auto-SELEX: a fully automated microfluidic platform for rapid discovery of high-affinity aptamers.

Aptamers are synthetic single-stranded oligonucleotides that fold into defined three-dimensional structures, enabling high-affinity and highly selective target recognition, and are increasingly explored as alternatives to antibodies in diagnostics and therapeutics owing to advantages in production cost, reproducibility, thermal stability, and ge...

#6 [12.0] Discovery and Cryo-EM-Guided Development of a Neuropilin-2-Binding Aptamer for Receptor Antagonism.

Receptor antagonists represent a major class of targeted cancer therapeutics, yet SELEX-based aptamer discovery often yields high-affinity binders that display limited functional blockade because epitope positioning is not explicitly selected. Herein, we report a multistage discovery and optimization workflow that integrates cell-SELEX, cryo-ele...

#7 [12.0] DNA-Engineered Dual-Signal Biomimetic Fusion Vesicles for Rapid Evaluation of Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a rare autoimmune disease with complex and variable clinical presentations that affects numerous organs and tissues. However, current diagnostic approaches provide limited insight into disease-associated molecular alterations and immune pathway activation. In this work, we report an exosome-capture-based sys...

#8 [11.7] Proximity-Induced Phosphatase-Recruiting DNA Feedback Switch for Self-Adaptive Modulation of Receptor Signaling and Cell Behavior.

Transmembrane receptors orchestrate cell fate decisions and maintain tissue homeostasis through exquisitely regulated signaling cascades, whereas their dysregulation drives disease initiation and progression. Although a variety of stimulus-responsive strategies have been developed to manipulate receptor activity, regulation of cellular processes...

#9 [11.7] Three-Dimensional In Situ Sensing and Spatiotemporal Imaging Analysis of Dual Targets in Steatotic Liver Disease.

Accurate monitoring of steatotic liver disease (SLD) remains challenging, particularly in capturing the spatial distribution of different types of SLD targets within a tissue-like complex physiological matrix. In this study, we developed a novel hydrogel-based three-dimensional (3D) in vitro fatty liver mimic model enabling simultaneous in situ ...

#10 [11.3] Multicompartment Drug Monitoring Reveals Paired Brain-Liver Kinetics and Selective Central Nervous System Barrier Permeability in Rats.

Characterizing drug distribution to target organs is of central importance to drug discovery, especially for compounds intended to reach the central nervous system (CNS). However, the current benchmark standard measurements, based on tissue homogenate, provide limited spatial and temporal resolution. Here, we use real-time electrochemical aptame...

Methodology