Aptamer 学术简报 — neurodegeneration — 2026-10-16

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 5 篇命中（aptamer 池 136 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [11.0] Label-Free Acoustic Wave Detection of Myelin Basic Protein for Monitoring of Neurodegenerative Disease

Myelin basic protein (MBP) is released into cerebrospinal fluid during demyelination and is therefore a promising biomarker for the detection of neurodegenerative diseases such as multiple sclerosis. For the label-free detection of MBP, we developed an antifouling aptasensor based on thickness shear mode sensing. DNA aptamers were immobilized on...

#2 [8.7] Multiplexed impedimetric zinc oxide nanorods-modified aptasensor on carbon ink-inscribed paper electrodes for the specific and sensitive co-detection of Alzheimer's and Parkinson's disease.

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), represent a growing health burden, while early diagnosis remains challenging because established diagnostic approaches, including cerebrospinal fluid analysis and neuroimaging, are invasive, expensive, and unsuitable for decentralized point-of-care testi...

#3 [8.0] Computationally guided engineering of an aptamer–gold nanoparticle aptasensor for ultrasensitive detection of α-synuclein in biological matrices

Early, reliable detection of α-synuclein (αSN) is critical for Parkinson's disease diagnosis, yet antibody-based assays remain limited by sensitivity, matrix effects, and cost. We report a label-free aptamer–gold nanoparticle nanobiosensor (G 12 Apt@AuNP) for non-invasive αSN detection in saliva. Molecular docking identified F5R1 as the aptamer ...

#4 [7.3] QR-code‑linked additive-engineered aptasensor for non-invasive impedimetric biosensing of neurodegenerative biomarker Aβ-42 with computational modelling validation for high selectivity

#5 [7.0] Achieving near single-molecule sensitivity in separation-free protein detection using engineered kinetic proofreading

Unlike nucleic acids, proteins cannot be directly amplified. Ultrasensitive detection must therefore couple efficient analyte-to-signal conversion with strong suppression of target-independent background. Consistently detecting ~100 molecules (below which Poisson sampling noise alone causes CV to exceed 10%) across protein targets in a format as...

Methodology