Aptamer 学术简报 — neurodegeneration — 2026-10-09

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 6 篇命中（aptamer 池 206 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.9] Online aptamer-based solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry for the determination of Alzheimer's disease biomarkers.

BACKGROUND: Reliable quantification of amyloid-β (Aβ) peptides in biological fluids is of major clinical and research interest in Alzheimer disease context. Conventional offline extraction approaches often involve labor-intensive manual steps and high solvent consumption, limiting throughput routine applications, reproducibility, and sustainabil...

#2 [10.5] Click chemistry ligation-initiated bisulfite-free assay on nanobeads for highly sensitive detection of site-specific 5 mC

5-Methylcytosine (5 mC) represents the most prevalent and functionally significant DNA modification in mammalian genomes. Aberrations in its status are intricately associated with the pathogenesis of various diseases, including cancer and neurodegenerative disorders. The ultrasensitive detection of low-abundance 5 mC in trace biological fluids, ...

#3 [9.3] Achieving near single-molecule sensitivity in separation-free protein detection using engineered kinetic proofreading

Unlike nucleic acids, proteins cannot be directly amplified. Ultrasensitive detection must therefore couple efficient analyte-to-signal conversion with strong suppression of target-independent background. Consistently detecting ~100 molecules (below which Poisson sampling noise alone causes CV to exceed 10%) across protein targets in a format as...

#4 [7.3] Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosomal function via Sirt3 signaling to ameliorate neurodegenerative pathology.

Neuroinflammation and lysosomal dysfunction in microglia are increasingly recognized as critical pathological drivers of Alzheimer’s disease, yet current anti-inflammatory or neuroprotective agents have limited brain delivery efficiency and cellular specificity. To address these challenges, this study proposes a novel nanotherapeutic paradigm ba...

#5 [6.7] Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus.

BACKGROUND: Mechanical ventilation is associated with acute and long-term cognitive dysfunction, yet the molecular pathways linking ventilator-induced lung injury (VILI) to brain injury remain poorly characterized. We previously demonstrated that peripheral IL-6 signaling mediates delirium-like phenotypes in a murine VILI model. Here, we use unb...

#6 [5.3] Vibrational Spectroscopy in Alzheimer's Disease Research and Diagnostics: From Molecular Biomarkers to Spectral Fingerprints.

Alzheimer's disease (AD) research is increasingly shaped by biologically anchored criteria and blood-based biomarker workflows, but the role of vibrational spectroscopy within this landscape remains difficult to define because infrared (IR), Raman, and surface-enhanced Raman scattering (SERS) methods measure different chemical information and ar...

Methodology