Aptamer 学术简报 — neurodegeneration — 2026-10-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 10 篇命中（aptamer 池 201 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.6] Online aptamer-based solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry for the determination of Alzheimer's disease biomarkers.

BACKGROUND: Reliable quantification of amyloid-β (Aβ) peptides in biological fluids is of major clinical and research interest in Alzheimer disease context. Conventional offline extraction approaches often involve labor-intensive manual steps and high solvent consumption, limiting throughput routine applications, reproducibility, and sustainabil...

#2 [12.3] Membrane-Coated DNA Nanoflowers Attenuate Cognitive Decline in Apolipoprotein E4 Mice.

APOE4-driven mitochondrial dysfunction is one of the important primary drivers of cognitive decline in neurodegenerative diseases. However, achieving mitochondrial-targeted drug delivery in the nervous system requires overcoming multiple barriers, necessitating the development of a safer and more efficient bionanoparticle drug delivery system. D...

#3 [10.0] Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosomal function via Sirt3 signaling to ameliorate neurodegenerative pathology.

Neuroinflammation and lysosomal dysfunction in microglia are increasingly recognized as critical pathological drivers of Alzheimer’s disease, yet current anti-inflammatory or neuroprotective agents have limited brain delivery efficiency and cellular specificity. To address these challenges, this study proposes a novel nanotherapeutic paradigm ba...

#4 [9.3] Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus.

BACKGROUND: Mechanical ventilation is associated with acute and long-term cognitive dysfunction, yet the molecular pathways linking ventilator-induced lung injury (VILI) to brain injury remain poorly characterized. We previously demonstrated that peripheral IL-6 signaling mediates delirium-like phenotypes in a murine VILI model. Here, we use unb...

#5 [9.2] Highly sensitive and specific high-throughput detection of Aβ42 in clinical specimens using a G-quadruplex-structured fluorescent aptamer analysis platform.

The early diagnosis of Alzheimer's disease (AD) relies on highly sensitive detection of the biomarker amyloid-β 42 (Aβ42). Currently used methods for detecting Aβ42, such as enzyme-linked immunosorbent assay (ELISA) and mass spectrometry, have limitations including insufficient sensitivity, high cost, and limited throughput. This study aimed to ...

#6 [8.9] Aptamer-Based Heterobifunctional Targeted Degraders in Disease Treatment.

Aptamers are short nucleic acid molecules that bind to targets with high specificity. Recognized as "chemical antibodies", they offer distinct advantages including strong programmability and ease of synthesis and chemical modification. Heterobifunctional targeted degraders were developed to address the challenges posed by traditionally "undrugga...

#7 [8.0] Vibrational Spectroscopy in Alzheimer's Disease Research and Diagnostics: From Molecular Biomarkers to Spectral Fingerprints.

Alzheimer's disease (AD) research is increasingly shaped by biologically anchored criteria and blood-based biomarker workflows, but the role of vibrational spectroscopy within this landscape remains difficult to define because infrared (IR), Raman, and surface-enhanced Raman scattering (SERS) methods measure different chemical information and ar...

#8 [7.0] Proteomic signatures during pregnancy: an exploratory cohort study of long-term health indicators.

BACKGROUND: Pregnancies complicated by fetal growth restriction (FGR) and preeclampsia are associated with increased long-term chronic disease risk. A blood test could possibly identify those at risk, opening the door to early interventions soon after delivery. Prior work in non-pregnant people have identified protein signatures associated with ...

#9 [6.3] Small Nucleic Acid Therapeutics for Ocular Diseases: Progress, Challenges, and Future Perspectives.

Ocular diseases remain a major global health challenge with substantial unmet therapeutic needs. Small nucleic acid therapeutics offer a precise strategy to regulate disease-related mRNAs or noncoding RNAs through base pairing, thereby modulating protein expression at the RNA level. Major modalities include antisense oligonucleotides, small inte...

Methodology