Aptamer 学术简报 — neurodegeneration — 2026-09-26

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 4 篇命中（aptamer 池 136 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.9] Membrane-Coated DNA Nanoflowers Attenuate Cognitive Decline in Apolipoprotein E4 Mice.

APOE4-driven mitochondrial dysfunction is one of the important primary drivers of cognitive decline in neurodegenerative diseases. However, achieving mitochondrial-targeted drug delivery in the nervous system requires overcoming multiple barriers, necessitating the development of a safer and more efficient bionanoparticle drug delivery system. D...

#2 [10.6] Aptamer-Based Heterobifunctional Targeted Degraders in Disease Treatment

Aptamers are short nucleic acid molecules that bind to targets with high specificity. Recognized as “chemical antibodies”, they offer distinct advantages including strong programmability and ease of synthesis and chemical modification. Heterobifunctional targeted degraders were developed to address the challenges posed by traditionally “undrugga...

#3 [10.1] Split malachite green aptamer transcription-based AND logic fluorescent platform: A novel approach for dual-miRNA detection in diabetes mellitus complicated with Alzheimer's disease

#4 [9.7] Vibrational Spectroscopy in Alzheimer's Disease Research and Diagnostics: From Molecular Biomarkers to Spectral Fingerprints.

Alzheimer's disease (AD) research is increasingly shaped by biologically anchored criteria and blood-based biomarker workflows, but the role of vibrational spectroscopy within this landscape remains difficult to define because infrared (IR), Raman, and surface-enhanced Raman scattering (SERS) methods measure different chemical information and ar...

Methodology