Aptamer 学术简报 — neurodegeneration — 2026-09-10

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 7 篇命中（aptamer 池 231 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [12.4] High-Performance Screen-Printed OECT-Inspired with Encased Cassette Based on PEDOT:GO for Sensitive and Specific Electrochemical Aptasensing of Aβ-42 in Management of Alzheimer's Disease.

Recently, substantial interest has emerged in developing point-of-care diagnostic devices for Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by the accumulation of beta-amyloid (Aβ1-42) peptides that act as critical biomarkers for early detection. In response to the growing demand for noninvasive and accessible ...

#2 [12.4] Preliminary Development of a Hybrid Aptamer and Antibody Fluorescent Lateral Flow Assay for Ultrasensitive Detection of Tau441 Protein in Serum: Toward Point-of-Care Diagnostics for Alzheimer's Disease.

A hybrid DNA aptamer and antibody-Europium nanoparticle (Eu NP) fluorescent sandwich lateral flow (LF) assay for Tau441 is described which works well in human serum with an apparent visible detection limit for Tau 441 of ~ 10 pg/ml or 1 pg of Tau protein. The same LF assay appears to detect phosphorylated threonine 217 Tau 441 (phospho Thr-217 T...

#3 [11.8] A signal-locked clamped hybridization chain reaction nanoamplifier for rapid and highly sensitive analysis of Aβ42.

Amyloid-beta 42 (Aβ42) is a core biomarker associated with Alzheimer's disease (AD), but accurate quantification of low-abundance plasma Aβ42 remains challenging because of matrix interference, limited assay sensitivity, and time-consuming procedures in conventional methods. Herein, we developed an enzyme-free fluorescence biosensing platform in...

#4 [11.5] DNA- and aptamer-based biosensors for Alzheimer's disease biomarkers toward clinical translation.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which early diagnosis remains a major challenge. DNA-based biosensors and aptamer-based biosensors have emerged as complementary platforms for the sensitive and selective detection of Alzheimer's disease biomarkers. DNA biosensors primarily detect nucleic acid biomarkers, i...

#5 [10.8] Photoelectrochemical highly efficient detection of β-amyloid 1-42 based on in-situ grown donor-acceptor covalent organic frameworks combined with dual-aptamer sandwich amplification strategy

Methodology