Aptamer 学术简报 — neurodegeneration — 2026-07-28

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 11 篇命中（aptamer 池 192 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [12.7] Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

Ultrasensitive detection of low-abundance protein biomarkers is crucial for early disease diagnosis but remains challenging for the conventional barcode beads-based suspension chip platform due to the limited detection sensitivity. Here, we report a conceptually novel reaction termed "radical-mediated in situ fluorescence dye deposition" (RIFD) ...

#2 [11.1] Development of an RNA aptamer as a therapeutic agent for synucleinopathies.

The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodegeneration. Despite the availability of symptomatic treatm...

#3 [10.8] Nonlinear hybridization chain reaction empowered CRISPR-based fluorescent aptasensor for ultrasensitive detection of β-amyloid 42

#4 [8.3] Aptamer-Based Detection of Chronic Traumatic Encephalopathy Predictive Biomarker S100B Using Laser Wave-Mixing Detection Coupled with Capillary Electrophoresis

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease associated with repetitive head trauma, for which there is currently no well-established antemortem diagnostic biomarker. In this report, a proof-of-concept experiment is described for conditions optimized for the selection and detection of aptamers against S100B, ...

#5 [8.3] Exosome-Mediated Drug Delivery: Emerging Opportunities in Cancer, Neurodegenerative Disorders, and Personalized Medicine

Exosomes are nanoscale, cell-derived membrane vesicles that mediate intercellular communication by transferring proteins, lipids, and nucleic acids between donor and recipient cells. Because they are biocompatible, exhibit low intrinsic immunogenicity, can be engineered for tissue-specific targeting, and are capable of crossing biological barrie...

#6 [8.3] Exosome-Mediated Drug Delivery: Emerging Opportunities in Cancer, Neurodegenerative Disorders, and Personalized Medicine

Exosomes are nanoscale, cell-derived membrane vesicles that mediate intercellular communication by transferring proteins, lipids, and nucleic acids between donor and recipient cells. Because they are biocompatible, exhibit low intrinsic immunogenicity, can be engineered for tissue-specific targeting, and are capable of crossing biological barrie...

#7 [7.7] Aptamer-carbon Nanotube Hybrids: Emerging Frontiers in BiomedicalDiagnostics and Therapeutics

Aptamers are single-stranded DNA or RNA molecules that exhibit remarkable affinity and specificity for a broad spectrum of biological targets, positioning them as compelling alternatives to antibodies in both diagnostics and therapeutics. Their ease of synthesis, chemical stability, and tunable binding properties make them highly adaptable for m...

#8 [7.0] An aptamer targeting TfR1 enhances ASO delivery to muscle tissue

Oligonucleotide based therapeutics continue to rise as a significant class of medicines for the treatment of human disease. However, achieving delivery to non-hepatic tissues remains a challenge in the field. While substantial advances have been realized, largely through the use of antibody or protein based targeting agents to tissues including ...

#9 [6.0] Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

Abstract Localized surface plasmon resonance (LSPR) technology is capable of detecting biomarkers in biological samples quickly and accurately outside the lab. LSPR is highly sensitive to the dielectric environment on the surface of metal nanostructures and can detect biomolecular binding through real‐time wavelength shift measurements. It is su...

#10 [5.7] Liquid crystal biosensing platform based on whispering gallery mode laser for Aβ42 detection.

Alzheimer's disease (AD) is an irreversible and progressively worsening neurodegenerative disorder. Amyloid beta (Aβ42) plays a crucial role in the early diagnosis of this disease. However, the concentration of Aβ42 in the blood is extremely low, which poses a challenge for Aβ42 detection. Herein, a liquid crystal (LC) biosensing platform based ...

Methodology