Aptamer 学术简报 — neurodegeneration — 2026-07-10

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 6 篇命中（aptamer 池 240 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.0] An aptamer-mediated EXPAR fluorescence biosensor for early and sensitive detection of Aβ42 and Aβ40.

BACKGROUND: Alzheimer's disease (AD) is a common neurodegenerative disorder with increasing cases worldwide. Early screening is important for AD prevention and treatment, but current methods still face many challenges. RESULTS: To address these challenges, we developed a simple and novel molecular beacon (MB) fluorescent biosensor. This sensor c...

#2 [12.6] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#3 [12.1] NMR characterization of the structure and interaction of an RNA aptamer targeting α-synuclein.

α-Synuclein (αSyn) is an intrinsically disordered protein whose aberrant aggregation is a hallmark of Parkinson's disease. C-terminally truncated αSyn variants promote aggregation and fibril formation of full-length αSyn, making them targets for diagnosis and therapy. sh1R6 is an RNA aptamer selected against a C-terminally truncated αSyn variant...

#4 [9.3] SELEX to Clinic: Evolution, Innovations and Applications of Aptamers in Precision Medicine

Aptamers are short, single-stranded DNA or RNA oligonucleotides selected in vitro via SELEX (Systematic Evolution of Ligands by Exponential Enrichment) that fold into defined 3-D structures and bind cognate targets with antibody-like affinity yet superior versatility. Thirty-five years after their simultaneous disclosure by Ellington & Szostak a...

#5 [9.3] SELEX to Clinic: Evolution, Innovations and Applications of Aptamers in Precision Medicine

Aptamers are short, single-stranded DNA or RNA oligonucleotides selected in vitro via SELEX (Systematic Evolution of Ligands by Exponential Enrichment) that fold into defined 3-D structures and bind cognate targets with antibody-like affinity yet superior versatility. Thirty-five years after their simultaneous disclosure by Ellington & Szostak a...

#6 [7.7] EXPRESS: Toll Like Receptor 4 (TLR4) in Neuroinflammation: From Acute Hemorrhagic Stroke to Chronic Neurodegeneration.

Subarachnoid Hemorrhage (SAH) remains a leading cause of morbidity and mortality worldwide. While the primary injury is defined by mechanical tissue disruption, the progression of secondary brain injury is largely driven by robust neuroinflammatory cascades initiated by blood derived damage-associated molecular patterns (DAMPs). Among the key me...

Methodology