Aptamer 学术简报 — neurodegeneration — 2026-07-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 6 篇命中（aptamer 池 244 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [10.6] Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.

Alzheimer's disease (AD) has become a neurodegenerative disease with an increasing incidence rate and a large economic and social burden worldwide. Amyloid-beta oligomer (AβO) has been confirmed as a key neurotoxic species and a core diagnostic biomarker in AD. Traditional methods for AβO detection have drawbacks, such as cumbersome operation, h...

#2 [10.3] An electrochemiluminescence aptasensor based on resonance energy transfer between MXene/prussian blue analog hollow spheres and MXene@ZIF-67 for sensitive detection of Alzheimer's disease biomarkers

#3 [10.0] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#4 [7.0] Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia.

IMPORTANCE: TMEM106B is a frontotemporal lobar degeneration (FTLD) genetic susceptibility factor, and TMEM106B protein aggregates are a feature of aging and neurodegeneration. Whether TMEM106B protein levels are associated with clinical features is unknown. OBJECTIVE: To investigate the clinical associations of cerebrospinal fluid (CSF) TMEM106B...

#5 [5.3] Novel aptamers targeting heparan sulfate for delivery of RNA therapeutics in Alzheimer's disease.

Heparan sulfate (HS) proteoglycans are abundant, sulfation-patterned glycosaminoglycans on brain cells and the neurovascular unit that interact with amyloid-β (Aβ) and tau, aggregate and propagate proteopathic species, and modulate cellular uptake pathways. Aptamers are short, chemically synthesized single-stranded nucleic acids that fold to for...

Methodology