Aptamer 学术简报 — neurodegeneration — 2026-06-24

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 4 篇命中（aptamer 池 168 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [9.3] Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia.

IMPORTANCE: TMEM106B is a frontotemporal lobar degeneration (FTLD) genetic susceptibility factor, and TMEM106B protein aggregates are a feature of aging and neurodegeneration. Whether TMEM106B protein levels are associated with clinical features is unknown. OBJECTIVE: To investigate the clinical associations of cerebrospinal fluid (CSF) TMEM106B...

#2 [7.7] Novel aptamers targeting heparan sulfate for delivery of RNA therapeutics in Alzheimer's disease.

Heparan sulfate (HS) proteoglycans are abundant, sulfation-patterned glycosaminoglycans on brain cells and the neurovascular unit that interact with amyloid-β (Aβ) and tau, aggregate and propagate proteopathic species, and modulate cellular uptake pathways. Aptamers are short, chemically synthesized single-stranded nucleic acids that fold to for...

#3 [7.3] Characterization of the plasma proteomic profile of dual trajectories in cognitive status and physical performance.

Dual declines in cognitive status and physical performance increase dementia risk but shared biological mechanisms between processes remain unclear. We investigated plasma proteomic signatures underlying dual decline in older adults from the Invecchiare in Chianti cohort (n = 774; age ≥ 60). Group-based trajectory models with up to 15 years of d...

Methodology