Aptamer 学术简报 — neurodegeneration — 2026-06-17

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 2 篇命中（aptamer 池 159 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [10.1] A label-free electrochemical aptasensor enables ultrasensitive and specific detection of neurofilament light.

Plasma neurofilament light chain (NfL) has been identified as a promising early-stage Alzheimer's disease (AD) biomarker, reflecting neuroaxonal degeneration at preclinical stages. However, its extremely low concentration in blood presents a major analytical challenge. Although single-molecule array (Simoa) assays provide exceptional sensitivity...

#2 [9.7] Characterization of the plasma proteomic profile of dual trajectories in cognitive status and physical performance.

Dual declines in cognitive status and physical performance increase dementia risk but shared biological mechanisms between processes remain unclear. We investigated plasma proteomic signatures underlying dual decline in older adults from the Invecchiare in Chianti cohort (n = 774; age ≥ 60). Group-based trajectory models with up to 15 years of d...

Methodology